Trial targets deadly lung cancer

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IMAGE: Associate Professor Sonja Klebe, leader of Asbestos Associated Disease research at Flinders University
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Credit: Flinders University

With more than 650 Australians diagnosed with malignant mesothelioma last year, Flinders University is leading new research to discover alternatives to chemotherapy and even prevent deaths by early detection in future.

One novel approach, using natural therapeutic benefits of curcumin, a key component of the spice turmeric, will be put to the test in a clinical trial in 2021 as part of world-leading research at Flinders University.

While asbestos is now banned from being used for new buildings, many houses still contain asbestos, so exposure during renovations is common. Australia has one of the highest per-capita rates of asbestos-related disease in the world.

Flinders University researchers are studying the safety and feasibility of using a form of intrapleural liposomal curcumins to benefit patient survival and quality of life – with fewer toxic side-effects than chemotherapy.

“That’s why it’s important to explore alternative therapies and facilitate early diagnosis to reduce suffering and support early intervention measures,” says Flinders University lead researcher Associate Professor Sonja Klebe.

As well, the researchers are looking for early diagnostic methods with a special lung fluid test. “In most cases, malignant mesothelioma is not diagnosed until it is in the late stages,” she says. “We’re hoping to find a way to test for the disease before it becomes invasive.”

Patients diagnosed with malignant mesothelioma, the cancer caused by asbestos exposure, experience poor survival of 6-12 months following diagnosis and a five-year survival of less than 5%. Therapeutic options are limited due to high resistance rates to chemotherapy and the advanced age of patients (median age 75).

Associate Professor Klebe’s team will test the safety and feasibility of intrapleural liposomal curcumin to benefit patient survival and quality of life. Future treatments are expected to have fewer toxic side-effects than chemotherapy.

In addition, the researchers are investigating methods to facilitate early diagnosis, using novel techniques on the lung fluid that is drained in the early stages of diagnosis.

“In most cases, malignant mesothelioma is not diagnosed until it is in the late stages,” she says. “We’re hoping to find a way to test for the disease before it becomes invasive.”

In time for Asbestos Awareness Month in November, the experts warn the high number of cases could persist for years with hundreds more cases of the deadly disease possible after latency of more than 30 years from work-related (builders, plumbers, gasfitters, mechanics and marine engineers) or other exposure. Firefighters may also be at risk after the devastating bushfires razed old buildings and sheds across Australia.

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See the latest research publications:
‘Malignant mesothelioma in situ: diagnostic and clinical considerations’ (2020) by E Pulford, DW Henderson and S Klebe published in Anatomical Pathology (Vol 52, Iss 6, page 635-642)
DOI: 10.1016/j.pathol.2020.06.010

See also:
The potential utility of GATA binding protein 3 for diagnosis of malignant pleural mesotheliomas (2020) by S Prabhakaran, A Hocking, C Kim, M Hussey and S Klebe has

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YoPro targets fitness fanatics with familiar faces

Danone’s high protein yogurt, YoPro, is sending the message to athletes and fitness fanatics that everything adds up, with a high intensity campaign from Emotive.

The campaign film features fitness and sporting personalities Andrew Papadopoulos, Kahn Porter, Abbie Taddeo, Xavier Cook and Ellia Green, who were selected and procured by Lampoon Group. The social media and PR agency also worked with Emotive on the influencer campaign that will support the films.

YoPro brand manager, Xavier Gonzalez, said the campaign had to directly target the brand’s key audience.

“We are thrilled to be launching ‘Every millimetre matters’. YoPro’s delicious high protein and no added sugar range has been developed for our core audience of pro-am athletes and fitness enthusiasts as a no compromise pre, during or post work out snack to help them on their journey to reaching their performance goals,” he said.

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The ‘Every millimetre matters’ campaign film will be cut down to 60 and 30 second spots, and will run across digital channels and social media.

“Brands love to overclaim,” said Emotive’s managing partner and head of strategy, Michael Hogg.

“With YoPro, we know a yoghurt probably isn’t going to be the difference between achieving your performance goals or not.”

“But as another little thing that can help you get closer by providing the superior protein you need, when you need it, why wouldn’t you?”

At the start of the pandemic, YoPro jumped on board the call for at-home workout programs, launching a free 66-day fitness challenge that featured some of Australia’s best athletes and consisted of over 100 pieces of content.

Credits

Client: YoPRO
Head of Marketing: Blanca Carbonell
Brand Manager: Xavier Gonzalez

Creative Agency and Production: Emotive
CEO: Simon Joyce
Managing Partner & Head of Strategy: Michael Hogg
Business Director: Marshall Campbell
Creative Director: Zane Pearson
Senior Creative & Director: Rory Pearson
Junior Copywriter: Cameron Burnett
Junior Art Director: Jackson Tate
Executive Producer: Hayley Ritz-Pelling
Producer: Michael Hollis
Production Manager: Alex Bray
Studio Manager: Rebecca Love-Williams
Editor: Tim Chivers and Spencer Austad
Designer: Tim Evans
DOP: Campbell Brown
Steadicam: Justin Besser

Sound design: Electric Sheep
Senior Sound Designer: Joe Mount
Executive Producer: Kate Stenhouse

Distribution: Emotive
Head of Distribution & Analysis: Jamie Crick

Social Media & PR Agency: Lampoon Group
CEO: Josh White
Social Account Director: Lauren Houghton
Social Account Manager: Liz Van Oyen
Talent & Partnerships Manager: Millie Dawson
Public Relations Manager: Emily Simons

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How Physical Fitness Training Boosts Resilience by Meeting Targets

Exercise not only rejuvenates healthy mind and body but also helps in fulfilling the targets of individual in several working fields. Fitness freaks who are indulged in different activities always prefer to take proper training from an instructor who can make them perfect in different categories like sports, jobs (Army, Navy) and different martial arts like Judo, Kung fu, and Karate. They seek the assistance of trainer because it is hard for them to set such objectives themselves.

Physical fitness training improves your performance in several categories of work. Intense workout and athletic body with resilience are essential for fields like army, police, navy, airlines and sports. Fitness guidance or training may help to fulfill one's target in those platforms.

Psychological Benefits of the Workout

Research has shown that exercise not only builds your body but also handles stress and anxiety. Physically active people have a lower rate of depression and other psychological issues. Some of the psychometric benefits of workouts are highlighted below:

  • Workouts can improve your mood.
  • Reduces symptoms or risk of depression and protects you from illness like hypertension and other mental disorders.
  • Sharpens the decision-making capacity of an individual.
  • Rejuvenates the power of endurance and increase inner solace.

Physical Benefit of Exercise

There are multiple benefits of physical activity if done in a correct way. Advantages of workouts are as follows:

  • Exercise controls weight and gives a proper shape of your body by balancing the Body Mass Index.
  • Health issues like diabetes, metabolic syndrome, high blood pressure, cholesterol, heart disease etc can be controlled by physical activities.
  • Fitness activity helps in strengthening muscles, bones, and joints.
  • It increases the chance of living longer.
  • Workout also helps to overcome insomnia and provide good sleep.

Physical Fitness Training Goals

Everyone has the idea about the benefits of a workout but few people are acquainted with the side affect of wrong exercise, which can be the major reason for multiple health issues or injuries. If you do not take proper guidance of a professional fitness instructor then it may be hard to meet the fitness goals. Following are the guidelines suggested by the fitness gurus:

  • They set up regular workouts.
  • Instructors always try to guide their clients through important steps and techniques to prevent injury while training.
  • Fitness trainers make their clients strong in the specific platforms of working by scheduling the appropriate workouts for their jobs or other activities.
  • For beginners, some steps are designed by the trainers so that the trainee does not feel difficulty in a workout routine.
  • Fitness instructors do not give overtraining, which may harm a beginner.
  • They suggest you follow a balanced diet chart according to the BMI of your body.
  • They make you start exercise with warm up and stretching.

Indulging in various types of physical activities may not offer fruitful result if you do not take professional guidance. Therefore, lessons provided by physical fitness training can be beneficial and help to reach the target in a specific time and boosts resilience …

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