Online Shopping Ireland: Best Irish websites county by county guide for supporting local businesses

The Irish Independent is helping readers to think local and shop local ahead of Christmas with the ultimate guide to shopping local in your county across Leinster, Ulster, Connacht, and Munster. It’s a handy guide to online shopping and the Irish websites that need your support – it could be the difference between ensuring we have shops to go back to when the pandemic ends or the creation of ghost towns.

LEINSTER

CARLOW
A Touch of Class

Helen Mullins’ A Touch of Class boutique boasts labels like Luis Civit and also Linea Raffaelli, a luxury occasion-wear collection with an emphasis on comfort. https://atouchofclasscarlow.com/

Coolanowle Food Hall

Close

Coolanowle Food Hall sells organic meat from the Mulhall Family’s farm on the Carlow/Laois border (stock photo)


Coolanowle Food Hall sells organic meat from the Mulhall Family’s farm on the Carlow/Laois border (stock photo)

contrastwerkstatt

Coolanowle Food Hall sells organic meat from the Mulhall Family’s farm on the Carlow/Laois border (stock photo)

Selling organic meat from the Mulhall Family’s farm on the Carlow/Laois border, this well-stocked food store carries a great range of local and Irish artisan food products. Shop in-person or online for delivery within 10km on Saturday mornings. Delivery is free for orders over €100. www.coolanowlefoodhall.ie

Ballyshane

Husband and Wife duo, Willie and Cheryl, create beautiful and sustainable wooden cheese and chopping boards using locally sourced Irish woods www.ballyshane.com

Lollipops and Daydreams

Based in Carlow, they make soft furnishings, with everything from aprons for children, bunting, themed blankets such as tractors, fairies, mini doll bedding and fabric names in a frame. lollipopsdaydreams.com

The Chocolate Garden

Established in 2001 by Jim and Mary Healy, The Chocolate Garden of Ireland is an award-winning family business making handmade chocolates. They create individual hampers that would be a perfect Christmas gift. https://chocolategarden.ie/

Electro City is one of the larger independent Irish electronics retailers. It has outlets in Hanover Rd, Carlow, Ormonde Business Park, Dublin Rd and Purcellsinch Kilkenny where it stocks a range of computers and electrical goods. www.electrocity.ie

DUBLIN
McNally Family Farm

The farm shop at the McNally’s organic farm in Balrickard, north Dublin has gone from strength to strength this year and now offers a host of artisan products as well as its own wonderful vegetables. You can order online for collection or simply turn up to visit the farm shop and little cafe, which has excellent coffees, sandwiches and home-bakes for takeaway. www.mcnallyfamilyfarm.ie

Omdiva

The Maker’s Market was due to open this weekend in the Om Diva store on Drury Street where Ruth Ni Loinsigh is like a fairy godmother to emerging and established designers. She has invited 20 designers, jewellers and artisans from all over Ireland to join her in the run-up to Christmas but November sales will be online. Come December 1, they can be viewed in a dedicated space on the first floor of the Drury Street space so expect talented potters to abstract artists, up and coming fashion designers to organic kids clothing producers. Omdivaboutique.com

Independent Cinemas in Dublin

Both the IFI and Light House cinemas are embracing the small screen with excellent VoD platforms

Read more

Goldfinch Bio Presents Clinical Data from Phase 1 Trial Supporting Advancement of GFB-887 as a Precision Medicine for Patients with Kidney Diseases

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Goldfinch Bio, a clinical stage biotechnology company focused on discovering and developing precision medicines for the treatment of kidney diseases, today announced for the first time results from its Phase 1 clinical trial evaluating GFB-887, a first-in-class highly potent and selective inhibitor of Transient Receptor Potential Canonical Channel 5 (TRPC5), in healthy volunteers. The data are being presented today at the virtual American Society of Nephrology (ASN) Kidney Week 2020 Annual Meeting.

Goldfinch Bio is developing GFB-887 as a precision medicine for patients with kidney diseases characterized by overactivation of the TRPC5-Rac1 pathway, including focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy (DN). Overactivation of the TRPC5-Rac1 pathway leads to injury of podocytes, which are cells lining the kidney that, in their healthy state, prevent essential protein loss (proteinuria). Injury to podocytes causes podocyte loss, proteinuria and, eventually, kidney failure. TRPC5-Rac1 pathway overactivation is the key cause of disease in a substantial portion of FSGS and DN patients, and there are currently no approved drugs that specifically target the TRPC5-Rac1 pathway in these diseases.

“We are excited to share these first-in-human data, which demonstrate that GFB-887 is well-tolerated and suggest a dose-dependent reduction in urinary Rac1, confirming GFB-887 target engagement in the podocyte,” said Anthony Johnson, M.D., President and Chief Executive Officer of Goldfinch Bio. “Suppressing the TRPC5-Rac1 pathway has the potential to deliver clinically meaningful benefit to patients by reducing proteinuria and, as a result, preserving native kidney function. Supported by the Phase 1 data, we are now underway with our Phase 2 TRACTION-2 study of GFB-887 in FSGS and DN, as we continue to advance our mission of protecting patients from the inevitability of dialysis and kidney transplant by delivering precision medicines for subsets of kidney disease.”

Data from the Phase 1 Clinical Trial

The primary objective of the randomized, double-blinded, placebo-controlled trial was to assess the safety, tolerability, pharmacokinetic (PK) profile and pharmacodynamics (PD) of GFB-887 in healthy volunteers. A key exploratory objective was to characterize changes in urinary Rac1. Urinary Rac1 concentration may predict therapeutic response to TRPC5 inhibition.

The study enrolled 70 subjects, who were randomized four to one to receive GFB-887 at seven dose levels (ranging from 5 mg to 900 mg) or placebo.

Primary Objective: Safety, Tolerability and PK Data

GFB-887 was observed to be well-tolerated at all doses. There were no dose-limiting toxicities, severe adverse events (AEs) or abnormalities in laboratory or clinical assessments. In total, 38 percent of subjects who received GFB-887 reported AEs, compared to 21 percent of subjects treated with placebo. GFB-887-treated subjects reported headache more frequently than placebo-treated subjects (28.6% versus 7.2% respectively). The only other AE that was reported in two or more GFB-887-treated subjects was nausea (3.6%). Slight, asymptomatic reductions in blood pressure were observed in subjects treated at the highest doses.

The PK profile of GFB-887 is consistent with once-daily dosing, with a half-life ranging from 55 to 68 hours. A single 40 mg dose was also shown to exceed the preclinical

Read more