Researchers from Canada’s McMaster University analyzed thousands of documents spanning 300 years — including personal wills and testaments, parish registers and the London Bills of Mortality — to search for patterns on how plague was spreading through the population.
There was a “striking acceleration” in plague transmission between the Black Death of 1348 and the Great Plague of 1665, researchers said in findings published Monday in the Proceedings of the National Academy of Sciences journal.
David Earn, a professor in the department of mathematics and statistics at McMaster and lead author of the research, told CNN that while plague cases in London doubled every six weeks in the 14th century, by the 17th century, they were doubling every week and a half.
“That’s an enormous difference,” he said.
But this was not simply a case of the disease becoming more virulent — evolutionary geneticist Hendrik Poinar told CNN that while the spread of the disease accelerated, genetic analysis to date tentatively suggests that it may have become less infectious.
“When there are shifts in the epidemiology of the disease, most of the shifts that occur can be translated to human intervention or things that go on outside of the actual genetics of the bug,” Poinar, a professor in the department of anthropology at McMaster and a co-author of the study, said.
The estimated speed of the epidemics, coupled with what we know about the biology of the plague, suggested that plague did not spread primarily through human-to-human contact during these centuries, but instead, growth rates for early and late epidemics are more consistent with bubonic plague, transmitted by the bites of infected fleas, the researchers said.
“A given pathogen can cause very different epidemics, whether it’s in the same place over time, or in different places,” Earn explained.
“The characteristics of the community can strongly influence the pattern of the epidemic,” he said. “And of course, the behavioral response of individuals can also influence the pattern of the epidemic,” he added.
The findings could also provide a blueprint to how the current pandemic and future pandemics could behave.
“Plague never went away and it won’t ever go away, and (SARS) CoV-2 will never go away,” Poinar told CNN, explaining that the virus, like the plague, has “natural reservoirs” in the population.
“Fortunately we have a phenomenal scientific community, you know across the globe, working … more or less together right now to