The Alliance for Regenerative Medicine Announces Record Sector Financing in 2020

The regenerative medicine sector attracted $15.9 billion in financing through just the first three quarters of the year, shattering the previous record of $13.5 billion

Washington, DC – ( NewMediaWire ) – November 19, 2020 – Global financing for the regenerative medicine and advanced therapy sector set an annual record of $15.9 billion through just the first three quarters of 2020, according to  data  released today by the Alliance for Regenerative Medicine (ARM), the leading international advocacy organization dedicated to realizing the promise of regenerative medicines.

Despite the COVID-19 pandemic, financing for the cell, gene, and tissue-based therapies sector surpassed the previous record of $13.5 billion set during full-year 2018.

“There is strength across all types of investment and stages of the pipeline, from early-stage cell-based immuno-oncology to late-stage gene therapies,” said Janet Lambert, CEO of ARM. “The outlook for patients has never been brighter.”

Investors remain bullish about the promise of profound, durable, and possibly curative regenerative medicines to treat a range of diseases and disorders.

Public financing continues to drive the sector, through both IPOs ($2.8 billion YTD) and follow-on financings ($5.7 billion YTD). At $4.1 billion year-to-date, venture capital financing is also on track to surpass the previous record of $4.3 billion set in 2019.

“The rapid advancement of the science behind regenerative medicine makes this a very dynamic time for investors and a hopeful time for patients,” said Jason Rhodes, a partner at Atlas Venture. “The breadth of approaches now available — from CRISPR to CAR-Ts to lentiviruses and non-viral gene therapies — enables us to pick the right tool for the specific biology that we’re addressing.”

Highlights from ARM’s third-quarter 2020 data include:

Gene therapy financing was $3.5B in Q3 2020 and $12 billion YTD, up 178% and 114% from 2019 levels respectively; cell therapy financing reached $3 billion in Q3 2020 and $11 billion YTD, up 97% and 242%, respectively; tissue-based therapy financing was $226 million in Q3 2020 and $311 million YTD, up 11% and 311% respectively.*

At the end of Q3 2020, there were 1,109 regenerative medicine clinical trials ongoing worldwide – 373 in gene therapy, 492 in cell-based immuno-oncology, 202 in cell therapy, and 42 in tissue-based therapies.

Of the 1,109 clinical trials, 388 target more prevalent diseases, including prevalent cancers (159), cardiovascular disease (35), diseases of the central nervous system (33), infectious diseases including COVID-19 (38), and diabetes (17).

There are 97 ongoing Phase 3 clinical trials, with regulatory decisions expected in the coming months in the US and Europe for several product candidates across cell, gene, and tissue-based therapies; cell-based immuno-oncology now comprises more than half of the 418 Phase 1 trials.

There are 1,026 regenerative medicine and advanced therapy developers active globally, up from 1,001 in our previous report covering the first half of 2020. Of the current total, 536 are active in gene therapy, 641 are active in cell therapy, and 135 are active in tissue-based therapies.

* Some companies utilize multiple technology types, and financings for

Read more

Connecticut residents dump 8,000 pounds of drugs, vaping material on record takeback day

People in Connecticut and across the nation safely discarded a record amount of unused prescription drugs and vaping materials as part of the federal Drug Enforcement Agency’s recent Drug Take Back Day.

The total cleared from medicine cabinets nationwide was 985,392 pounds, or about 493 tons of medication dropped off at 4,587 collection sites, the agency recently announced.

In the six New England states, 115,944 pounds of expired, unused prescription drugs, electronic vaping devices and cartridges were collected at 586 sites. That’s more than four times the amount collected in the region (25,810 pounds) during the first Drug Take Back Day in September 2010.

In Connecticut, the total weight collected last week was about 8,000 pounds, compared with about 5,800 pounds three years ago. In total, about 13.6 million pounds or prescription drugs nationwide, including 122,245 pounds in Connecticut, has been collected since the program started, according to the DEA.

Collections at the semi-annual event (in April and October) are anonymous, and the drugs are incinerated at a waste-to-energy plant, Special Agent Timothy Desmond of the agency’s New England Division office said Monday.

Drugs dumped in the trash could be retrieved by people who would take them or sell them or by children, and some drugs flushed down the toilet can contaminate the water supply, the DEA says.

“The bottom line is that removing Rx medicines from the nation’s homes, where they could be stolen and abused by family members and visitors, including children and teens, is very important,” Desmond said.

Rates of prescription drug abuse in the U.S. are alarmingly high, according to the DEA, as are the number of accidental poisonings and overdoses due to these drugs.

The recent Drug Take Back Day was the second event in which the DEA accepted vaping devices and cartridges at any of its drop off locations as long as the lithium batteries were removed, Desmond said.

“DEA is doing all it can to help dispose safely of vaping devices and liquids to get these products off our streets and out of the hands of children,” he said.

In East Hartford, citizens turned in over 100 pounds of unwanted and unused prescription drugs, police spokesman Lt. Josh Litwin said. East Hartford, like some other police departments, also has a year-round drop box for unwanted drugs in the lobby of the public safety complex at 31 School St. Collections are limited to prescription medications, pills, capsules and caplets. Prohibited items include intravenous bags, sharps (anything with a needle or lance), Epi-pens, patches, gels, medications in tubes and liquids.

“The Pharmaceutical Collection Program reduces the risk of prescription drug diversion and abuse, sickness and hospitalizations attributable to inappropriate or outdated medication consumption and environmental damage including groundwater contamination and non-point watercourse pollution,” Mayor Marcia Leclerc said. “Medication disposal is a major public health and safety concern.”

Jesse Leavenworth can be reached at [email protected]

———

©2020 The Hartford Courant (Hartford, Conn.)

Visit The Hartford Courant (Hartford, Conn.) at www.courant.com

Distributed by Tribune Content Agency, LLC.

Read more

New Hampshire Reports Record High Positive COVID-19 Test Results

CONCORD, NH — Gov. Chris Sununu, R-NH, issued a weekend statement Saturday after state health officials reported the highest single day of new COVID-19 positive test results — 205, including 31 children.

The new test results were reported after 7,927 specimens were collected Friday and prior days of tests were updated slightly from previous reports. A little more than 1,100 test results are pending for a polymerase chain reaction test positivity rate of 1.6 percent.

“The situation here in New Hampshire remains very serious, the data shows that community transmission is increasing, and we expect cases to rise,” Sununu said. “We must all remain vigilant in our daily lives. As we enter these winter months, it will be more important than ever to wear your mask, practice social distancing, and maintain proper hand hygiene.”

Nearly a quarter of the new test results, 50, came from Rockingham County with 27 living in Hillsborough County outside of Manchester and Nashua, 19 residing in Nashua, and 13 living in Merrimack.

State officials are still investigating the residency of eight cases.

Fifty-three percent of the new positive test results were female.

The state reported that 42 people are currently hospitalizations while only one of the new cases has no identified risk factors.

Accumulatively, 11,084 people have contracted COVID-19 in New Hampshire with 1,338 currently infected and 9,263, 84 percent, having recovered from the virus.

The State Joint Information Center also announced the 483rd death in the New Hampshire — a woman who was 80 years of age or older and lived in a long-term care setting in Hillsborough County.

More than 345,000 people have been tested for the coronavirus with nearly 617,00 PCR tests being administered by the state and 4,400 people under public health monitoring.

More Possible Restaurant Exposures

Both state and Nashua health officials issued alerts during the past 24 hours about possible restaurant exposure to the public.

Nashua Public Health is investigating potential community exposure related to a person with a confirmed COVID-19 diagnosis at the Texas Roadhouse on 580 Amherst St. The potential community exposure occurred in the bar area between 3 and 10 p.m. on Oct. 22, and 11 a.m. to close on Oct. 23.

“The health and safety of our staff and customers is our top priority,” Eric Martin, the restaurant’s director of food safety. “We have been following CDC guidelines for cleaning and disinfecting our facility. We follow all reopening guidance for food service establishments from the state.”

Public health is investigating the situation and notifying any known close contacts directly but if you were at the restaurant during those dates, you should self-quarantine, monitor for symptoms — sore throat, congestion, runny nose, headache, muscle ache, fatigue, new loss of taste or smell, fever, cough, shortness of breath, nausea, vomiting, or diarrhea, and get tested.

State health officials said contact tracers were investigating another possible community exposure in Merrill’s Tavern and Stagecoach Grille at the Atkinson Resort & Country Club between 11 a.m. and 11:30

Read more

Coronavirus Live Updates: New U.S. Cases Hit Fresh Record

Nearly 46 million people have now been infected with the coronavirus world-wide, and nearly 1.19 million have died.

U.K.: Prime Minister Boris Johnson’s cabinet was due to meet Saturday to discuss plans for a new nationwide lockdown in England to curb the virus’s spread, according to a government official, who stressed a final decision hasn’t been made. Scientists at Imperial College London estimate infections are running at almost 100,000 a day in England, and hospitalizations and deaths are creeping up. The seven-day average for deaths hit 213 on Tuesday, its highest tally since May.

The government has been experimenting with localized restrictions in England but cases have continued rising. Scotland, Wales and Northern Ireland set their own public-health policies and have already closed some businesses and imposed curbs on household mixing. Mr. Johnson is due to hold a televised press conference at 4:00 p.m. London time on Saturday.

Greece: New restrictions, including mandatory mask wearing indoors and outdoors, will be take effect in Greece starting Tuesday. Other measures include a midnight to 5 a.m. curfew, and university courses will revert to online learning. In the Athens region and northern Greece, where the virus is circulating at higher levels, the government has also ordered the closure of bars, restaurants, theaters, museums and gyms.

While Greece has among the lowest infection rates in Europe, new cases are rising rapidly. Announcing the new measures, Greek Prime Minister Kyriakos Mitsotakis said the goal was to prevent the virus from spreading out of control.

“We must act now, before the intensive-care units are overwhelmed by people fighting for their life. Now, while we still have the ability to detect and track cases,” he said in a televised address.

India: The new-case count was below 50,000 for the sixth day in a row, with the country reporting 48,268 cases over the preceding 24 hours, and 551 deaths. Confirmed cases now exceed 8.1 million, with a death toll of 121,641.

Japan: The 778 new cases reported Saturday pushed the total past 100,000, and the 11 deaths brought the toll to 1,755. Starting Sunday, the government will allow business travelers returning from trips of seven days or less to any country to skip the two-week quarantine, provided they meet conditions including a negative test result.

The government has also lowered travel alerts on nine countries including China, South Korea and Australia. From Sunday onward, travelers from those countries won’t be required to take a coronavirus test upon arrival.

South Korea: With 127 new Covid-19 cases reported, it was the fourth consecutive day above 100. Locally transmitted infections have been rising this week, with new clusters around workplaces and social gatherings. Local authorities are on high alert this weekend, concerned that Halloween festivities could prompt a fresh wave.

China: Mainland Chinese authorities reported six new locally transmitted symptomatic cases, all in and around the city of Kashgar in the far western Xinjiang region and previously classified as asymptomatic. Chinese health authorities typically highlight and focus on positive cases showing

Read more

Illinois sets record for coronavirus cases for third day in a row

Illinois continues to shatter records for new known coronavirus cases, setting another high mark for the third day in a row.

State public health officials on Saturday reported 7,899 new COVID-19 cases, eclipsing Friday’s single-day record of 6,943 cases. On Thursday, the state reported 6,363 cases, which set a record at the time.

Along with the record number of new cases, state health officials announced 46 more fatalities on Saturday bringing the statewide death toll to 9,757 since the pandemic began.

The high number of cases comes as Public Health Director Dr. Ngozi Ezike urged people to make “pandemic-guided decisions” and to avoid in-person gatherings on Halloween weekend.

Ten of 11 Illinois regions are now operating under tighter restrictions under Gov. J.B. Pritzker’s reopening plan, including a ban on indoor dining and bar service, as the coronavirus continues its statewide resurgence.

A chunk of east-central Illinois that includes Champaign-Urbana and Decatur is the latest to join the list after its seven-day rolling positivity rate on coronavirus tests hit 8.6% on Tuesday, exceeding the state-established threshold of 8% for the third straight day and triggering the reopening rollback. The restrictions also include a 25-person limit on gatherings, down from 50.

The return of restrictions has proved controversial, with some restaurants vowing to continue indoor dining. Pritzker ordered closures for indoor dining last week in DuPage, Kane, Will and Kankakee counties. A similar restriction took effect in suburban Cook County on Wednesday and in Chicago on Friday. Lake and McHenry counties are to follow Saturday.

The state has reported 410,300 confirmed infections since the pandemic began. The seven-day statewide positivity rate, covering Oct. 24-30, — is 7.5%.

———

©2020 the Chicago Tribune

Visit the Chicago Tribune at www.chicagotribune.com

Distributed by Tribune Content Agency, LLC.

Source Article

Read more

US records 97,000 new COVID-19 cases, shattering daily record

The U.S. recorded roughly 97,000 new coronavirus cases Friday, shattering the previous record for the highest number of new cases in a single day.



a man riding a skateboard up the side of a road: coronavirus COVID-19 third wave community spread peak spring summer fall anthony fauci trump pandemic time graphic data record breaking daily cases


© Getty Images
coronavirus COVID-19 third wave community spread peak spring summer fall anthony fauci trump pandemic time graphic data record breaking daily cases

Data from the COVID Tracking Project showed there were 97,080 new cases Friday, ushering in an alarming new milestone that comes as dozens of states across the country see spikes in infections. The figure broke the previous record of 88,521 new coronavirus cases, which had been set on Thursday.

The nationwide surge in cases comes just ahead of a winter season during which experts say the increase will be exacerbated, as social gatherings move indoors where the virus can spread more easily.

“This is the hardest point in this pandemic right now – the next two months,” Scott Gottlieb, the former commissioner of the Food and Drug Administration, said during an interview on CNBC’s “Squawk Box” on Thursday. “We can’t give up our guard right now.”

The rise in cases virtually confirms that the coronavirus pandemic will be a top issue in the election next week, with polls showing large swaths of voters already saying the virus outbreak is their No. 1 issue.

The most serious outbreaks are being found in crucial political battlegrounds in the Midwest, including Wisconsin, which saw more than 5,000 new cases Friday.

The president has maintained the country is “rounding the turn,” but Democrats have torn into the Trump administration’s response to the pandemic, noting his dismissal of guidance from government health experts.

“President Trump’s decision to mislead the public about the severity of the crisis, his failure to listen to scientists about how to keep Americans healthy, and his refusal to implement a coordinated national plan to stop the coronavirus have all contributed to devastating results: more than 227,000 Americans dead, more than 8.8 million Americans infected, and a dangerous virus that continues to spread out of control nine months after it reached our nation’s shores,” a report from the House Select Subcommittee on the Coronavirus Crisis said Friday.

Continue Reading

Source Article

Read more

US shatters daily coronavirus record with nearly 90,000 new infections Thursday

The US has shattered the daily coronavirus record, with almost 90,000 new infections reported on Thursday and close to 1,000 deaths, as the US approached a world-topping 9m cases and experts warned of death rates more than doubling by mid-January.



a person wearing a costume: Photograph: Elaine Thompson/AP


© Provided by The Guardian
Photograph: Elaine Thompson/AP

The sobering data and scientific outlook show a pandemic veering further out of control in America even as the president and his son hammered a public message dismissing the grim realities.

According to figures from Johns Hopkins University of Medicine, the US had a total of more than 8.9 million cases on Friday, and was expected to soon cross the nine million mark. So far 228,677 people have died, the most in the world by a significant margin.

The USrecorded its highest one-day total of new coronavirus infections of the pandemic, with 88,521 new cases reported on Thursday – a rise of 9,540 on the previous day. The death toll for the 24-hour period was 971.

Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday and a number of state setting up overflow field hospitals and governors sending military helpers.

Donald Trump responded to the surge with a Friday morning tweet blaming case numbers on increased testing. “More Testing equals more Cases. We have best testing. Deaths WAY DOWN. Hospitals have great additional capacity! Doing much better than Europe. Therapeutics working!”



a person wearing a costume: Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday.


© Photograph: Elaine Thompson/AP
Hospitalisations are soaring in all but 11 states, according to the Covid Tracking Project, with more than 46,000 people in hospital on Thursday.

His eldest son, Donald Trump Jr, said in an interview on Fox that deaths were “almost nothing.”

Related: Donald Trump Jr and father play down Covid deaths as daily toll nears 1,000

But experts warned that conditions are likely to worsen sharply going into winter and predicted that death rates could more than double by mid-January.

The Institute for Health Metrics and Evaluation at the University School of Medicine said in its latest forecast that the death toll could hit 514,000 by the middle of January and added it was most likely that by that time 2,250 Americans will be dying every day from Covid-19, more than twice the current rate.

“The fall/winter surge should lead to a daily death toll that is approximately three times higher than now by mid-January. Hospital systems, particularly ICUs, are expected to be under extreme stress in December and January in 18 states,” it said.

The president continued to insist that the country is “rounding the turn”, arguing against taking stricter measures to combat the pandemic and told a campaign rally on Saturday “you don’t see death”.

“This is the hardest point in this pandemic right now – the next two months,” Scott Gottlieb, former commissioner of the US Food and Drug Administration (FDA), told CNN.

But with the election just days away, cases are soaring in every competitive state. In 13 potential

Read more

U.S. breaks daily record for coronavirus cases with over 91,000 new infections

(Reuters) – The United States broke its single-day record for new coronavirus infections on Thursday, reporting over 91,000 new cases, as hospitalizations also hit new highs in many states, according to a Reuters tally.

The spike in cases comes less a week before the presidential election on Tuesday.

Among the hardest hit by the latest COVID-19 surge are hotly contested states such as Ohio, Michigan, North Carolina, Pennsylvania and Wisconsin that will play an important role in deciding whether Republican President Donald Trump gets a second term or Democratic challenger Joe Biden becomes president.

The virus is also rapidly spreading to record levels in Europe, with France and Germany announcing nationwide lockdowns this week.

The previous one-day record for U.S. cases was 84,169 on Oct. 23. Globally, India holds the record for new cases in a single day at 97,894 infections on Sept. 17.

The White House coronavirus task force said the nation is heading in the wrong direction and warned of an “unrelenting” spread that requires aggressive action to curb new infections.

On Thursday, 12 states set one-day records for new cases: Illinois, Indiana, Maine, Michigan, Minnesota, Missouri, Nebraska, New Mexico, North Carolina, North Dakota, Ohio and Oregon.

In addition to new infections, deaths and hospitalizations are also rising. For the third time in October, more than 1,000 people died of the virus in a single day on Thursday.

Over 229,000 people have died from COVID-19 in the United States, the world’s highest death toll.

The number of hospitalized COVID-19 patients has risen over 50% in October to 46,000, the highest since mid-August.

(GRAPHIC: COVID-19 global tracker – here)

(GRAPHIC: Where coronavirus cases are rising and falling in the United States – here)

Reporting by Lisa Shumaker in Chicago; Editing by Bill Berkrot

Source Article

Read more

U.S. Hits Record as Global Cases Top 45 Million: Virus Update

(Bloomberg) — U.S. new cases topped 89,000, setting a daily record, as the outbreak intensifies ahead of next week’s presidential election. Global infections surpassed 45 million, with Europe also grappling to control a renewed surge in the disease across the continent.

Loading...

Load Error

German cases exceeded 500,000 after a gain of more than 19,000 through early Friday, confirming a trend that Chancellor Angela Merkel has characterized as a “dramatic situation.” France’s economy staged a record rebound in the third quarter, but that recovery now risks being derailed by new government restrictions. Poland is set to announce new measures to curtail its outbreak and Ukraine reported records in both deaths and infections.

In the U.S., infections are again on the rise in New York and New Jersey, while Midwest states are suffering a record outbreak. Anthony Fauci, the government’s top infectious disease doctor, predicted it could take until the end of 2021 at least for U.S. social life to return to normal even with an effective vaccine.

Key Developments:

Global Tracker: Cases surpass 45 million; deaths topped 1.18 millionMnuchin faults Pelosi as stimulus blame game heats upOperation Warp Speed could shape up to be an $18 billion bargainECB pushes governments to get on with spending in virus battleHow do people catch Covid-19?: QuickTakeVaccine Tracker: Clinical trials restart, providing hope

Subscribe to a daily update on the virus from Bloomberg’s Prognosis team here. Click CVID on the terminal for global data on coronavirus cases and deaths.

Sweden Earmarks More Cash for Testing (2:50 p.m. HK)

Sweden’s government has underestimated the cost of testing and tracing Covid-19 patients and the money that’s been earmarked for the purpose is now running out, TV4 reports.

The government will allocate an extra 3 billion kronor ($336 million) to pay for testing through the end of the year, bringing the total cost for testing and infection tracing this year to almost 10 billion kronor, according to the report.

Poland to Announce Restrictions on Friday (2:45 p.m. HK)

Poland’s health-care system is “stretched to its limits,” Michal Dworczyk, chief of staff in Prime Minister Mateusz Morawiecki’s office, says in interview with public radio 1.

Morawiecki has asked biggest state-run companies to build temporary hospitals in order to add more than 3,000 beds to treat Covid-19 patients.

Swiss Re Adds $500 Million to Reserves (2:31 p.m. HK)

Swiss Re added another $500 million in reserves for future claims as it warned about the high uncertainty that remains because of the coronavirus pandemic.

The re-insurer reported a net loss of $691 million for the first nine months of the year, driven by the increase in reserves it had to take for future claims, as the virus resurges and the threat of more lockdowns looms.

Lonza, AstraZeneca to Manufacture Antibody Combination (2:19 p.m. HK)

Lonza and AstraZeneca agreed to manufacture a combination of two long-acting antibodies for Covid-19 treatment called AZD7442, according to an SGX filing.

AZD7442 is currently in Phase 1 clinical studies and AstraZeneca plans to advance it into

Read more

Task force sees ‘unrelenting’ COVID-19 spread; daily U.S. cases up by record 91,000

WASHINGTON (Reuters) – The White House coronavirus task force warned that much of the country is in the grips of an “unrelenting” surge in COVID-19 cases and urged tough countermeasures, as the number of U.S. infections reported on Thursday hit a new daily record of more than 91,000.

FILE PHOTO: Healthcare workers wearing powered air purifying respirator (PAPR) hoods process COVID-19 test samples at a drive-thru testing site operated by Avera Health inside the former Silverstar Car Wash, as the coronavirus disease (COVID-19) outbreak continues in Sioux Falls, South Dakota, U.S., October 28, 2020. REUTERS/Bing Guan/File Photo

The hardest-hit regions in the West and Midwest encompass a number of battleground states expected to play a pivotal role in Tuesday’s U.S. presidential election contest between Republican incumbent Donald Trump and his Democratic challenger, Joe Biden.

“We are on a very difficult trajectory. We’re going in the wrong direction,” said Dr. Anthony Fauci, a leading task force member and director of the National Institute of Allergy and Infectious Diseases.

Fauci, the nation’s top infectious disease expert, said coronavirus cases were on the rise in 47 states, and patients were overwhelming hospitals across the country.

“If things do not change, if they continue on the course we’re on, there’s gonna be a whole lot of pain in this country with regard to additional cases and hospitalizations, and deaths,” Fauci said in a CNBC interview on Wednesday night.

The White House coronavirus task force has warned states in the middle and western parts of the country that aggressive measures will be necessary to curb the virus’ spread, according to weekly state reports seen by CNN.

“We continue to see unrelenting, broad community spread in the Midwest, Upper Midwest and West. This will require aggressive mitigation to control both the silent, asymptomatic spread and symptomatic spread,” one state’s report said.

The ominous assessment was echoed on Thursday by Dr. Ashish Jha, Brown University’s dean of public health, who told Reuters, “things are very, very bad in the United States right now.”

“We are having some of the largest breakouts that we’ve had during the entire pandemic,” he said, adding that the initial waves of infections last spring were more localized.

“And nine, 10 months into this pandemic, we are still largely not quite prepared.”

At least a dozen states – Illinois, Indiana, Maine, Michigan, Minnesota, Missouri, Nebraska, New Mexico, North Carolina, North Dakota, Ohio and Oregon – reported record one-day increases in COVID-19 cases on Thursday, according to a Reuters tally.

Seventeen states reported a record number of hospitalizations, a metric that has soared across the country and is independent of how much testing is being done.

Nationally, health authorities on Thursday confirmed 91,248 more people tested positive for COVID-19 over the past 24 hours, the highest single-day increase in cases reported to date, according to a Reuters tally. The previous 24-hour record tally was 84,169 cases, set just last Friday.

The number of Americans hospitalized with COVID-19 stood at

Read more