Carrot-based Japanese herbal medicine may improve muscle complications associated with COPD

Chronic obstructive pulmonary disease (COPD) is a lung disease caused by long-term inhalation of harmful gases such as cigarette smoke. Scientists have recognized deterioration of muscle tissue, known as, as a secondary effect of damaged lungs. This frailty makes it difficult for individuals to move around and exercise, which is turn worsens the state of their lungs, causing an endless downward spiral in overall health.

Exercise therapy is the only established treatment for the skeletal muscle complications of COPD, however, depending on the severity of sarcopenia frailty in the patient, such treatment may not be possible. This imbalance has become an urgent issue to address. Ninjin’yoeito is a carrot-based Japanese herbal medicine commonly given to people recovering from anorexia and physical weakness after illness or surgery for its supplementary effect in restoring physical strength. Also, the medicine has been seen to improve muscle mass loss in aging mice through the activation of PGC-1α- a protein involved in improving muscle function.

Based on this, we hypothesized that Ninjin’yoeito enhances PGC-1α expression in skeletal muscle and may improve muscle complications associated with COPD.”


Kazuhisa Asai, Associate Professor, Osaka City University Graduate School of Medicine

He led a research group in testing this hypothesis by including Ninjin’yoeito in the diet of mice who had been exposed to cigarette smoke for 12 weeks. Their findings were published online in the international scientific journal International Journal of Chronic Obstructive Pulmonary Disease on November 27, 2020.

Professor Asai’s team measured the lower leg muscle mass of the smoke-exposed group of mice with a microCT and noticed they had atrophied, like human COPD patients. However, he saw no such change in muscle mass with the experimental group of mice, suggesting that the addition of the carrot-rich medicine cancels out the effects of sarcopenia frailty.

“We believe that this is a useful finding and that Ninjin’yoeito may break the vicious circle of sarcopenia frailty in COPD patients”, adds Associate Professor Asai. “We would like to consider clinical trials in the future.”

Source:

Journal reference:

Miyamoto, A., et al. (2020) Ninjin’yoeito Ameliorates Skeletal Muscle Complications in COPD Model Mice by Upregulating Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Expression. International Journal of Chronic Obstructive Pulmonary Disease. doi.org/10.2147/COPD.S280401.

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5 Fitness Tips on Fat Loss and Muscle Gain

One of my challenges for the month of May is to add a decent amount of muscle while losing fat. I have not done any measuring. I weigh myself once a week or less and look at myself in the mirror a lot. I am also well aware of my energy levels throughout the day as well as my fitness progress.

About a week and a half ago I did 14 straight pull-ups. I will test myself again in June. If I manage to do 20 then I would say its pretty clear I have gained a fair amount of muscle while losing fat. If I beat my 8:33 time in the Primal Blueprint Fitness Challenge then I will be certain that my fitness capacity has expanded.

The following tips are my personal fitness tips in order to gain muscle and lose fat. I do A LOT of reading. This includes The 4 Hour Body which I dove into last night. I am not an expert but am progressing at a reasonable rate while loving life.

1) Quit Cardio

It is completely unnecessary. Two summers ago I thought I enjoyed running. I ran in 9 5 Kilometer runs over 2 summers in shoes. My best time was 21:03 which is about a 6:47 mile pace. In reality I hated it. I love to compete but running sucked ass. I love to hike and jog barefoot or in my Vibram Five Fingers. I will run in 5 kilometer in the future but will gladly take a 30 minute finishing time while running barefoot.

When you engage in long and intense cardio you get hungry. You then eat to make up for it. This is the main reason why most diets fail. Unless you want to starve yourself then quit cardio. It does nothing except harm you.

A brisk walk, jog, hike or any other activity that has you moving frequently at a slow pace is perfect.

2) Don’t Go to Failure

When lifting heavy things, such as your body, go as close to failure as possible without going to failure. Why do I advise that you don’t go 110%? Because you will be sore the next day and will hate it. At least this is where I stand. I engage in a very intense primal fitness challenge once per month. I am sore for the next 2 days. I would literally hate my life if this was the case after every intense strength workout I did.

Go intense. Be smart. Enjoy the workout. Feel amazing.

3) Focus on Proper Form

I have been really focusing on form this month. Ten picture perfect push-ups is a hell of a lot better than twenty quick, half-hearted push-ups. Go slow and concentrate on what you are doing.

I also think of symmetry. For a pull-up most of us will pull ourselves up and then drop down as quickly as possible. I have been slowly lowering myself down. Guess what? I am able to do …

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