Study and Editorial on Cannabinoid Hyperemesis Syndrome (CHS) Published in The Journal of Investigative Medicine (JIM)

BEVERLY, Mass., Nov. 30, 2020 /PRNewswire/ — The December issue of The Journal of Investigative Medicine (JIM), the journal of the American Federation for Medical Research (AFMR), is publishing both a study and editorial on the important topic of Cannabinoid Hyperemesis Syndrome (CHS).

The research is entitled Cannabinoid Hyperemesis Syndrome: Definition, Pathophysiology, Clinical Spectrum, Insights into Acute and Long-Term Management.

The Study: Although cannabinoid hyperemesis syndrome (CHS) was first reported more than 15 years ago, it still remains an unfamiliar clinical entity among physicians worldwide. With the legalization of marijuana in many states, CHS will become an increasingly prevalent clinical entity, so educating about CHS is an important goal, particularly for emergency department physicians who generally first encounter these patients.

Authors: Mahesh Gajendran MD, Joshua Sifuentes, MD, Mohammad Bashashati, MD and Richard McCallum, MD of Texas Tech University Health Sciences Center, El Paso.

The editorial, Cannabinoid Hyperemesis Syndrome: The Conundrum Is Here to Stay, is authored by Ron Schey, MD, University of Florida Health, Jacksonville.

Other December highlights include:

  • Review: Advances in the management of atrial fibrillation with a special focus on nonpharmacological approaches to prevent thromboembolism: A review of current recommendations.
    Authors:Harsha S. Nagarajarao, MD, Richard McCallum, MD, Chandra Prakash Ojha, MD, Adriana Camila Mares, MD and Ahmed Ibrahim, MD of Texas Tech University Health Sciences Center El Paso; Malini Riddle, MD of Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso; Timir Kumar Paul, MD of East Tennessee State University; Vineet Gupta, MD of University of California San Diego; David Alan Baran, MD of Sentara Healthcare; Bharat Ved Prakash, MD of Texas Tech University Health University Health Sciences Center El Paso, Transmountain Campus; Amogh Misra, MD of The University of Texas at Austin; Moeen Abedin, MD and Venkatachalam Mulukutla, MD of University Medical Center of El Paso; Archana Kedar, MD of University of Louisville School of Medicine.
  • Faculty Development & Education:Academic Collaborations with Industry — Lessons for the Future.
    Authors: S. Sethu K. Reddy, MD of Central Michigan University College of Medicine, Mount Pleasant; Shing Chao, MD of College of Medicine, Central Michigan University, Saginaw.

About the Journal of Investigative Medicine: The Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research.

About the American Federation for Medical Research: The American Federation for Medical Research (AFMR) is an international, multidisciplinary association of scientists engaged in all areas of biomedical and patient-oriented research — from the laboratory to translational to clinical. It works to foster the development of future generations of clinical scientists and investigators through its own initiatives, as well as encouraging public, private, and governmental investment

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Emmes Employees Co-Author COVID-19 Vaccine Report for the New England Journal of Medicine

ROCKVILLE, Md., Nov. 2, 2020 /PRNewswire/ — Emmes today announced that it provided the data and statistical analysis support for a Phase 1 clinical trial of an investigational COVID-19 vaccine, mRNA-1273, that enrolled adult volunteers.   The results of this clinical trial were published in the New England Journal of Medicine (NEJM) on September 29.

Three Emmes employees were among the co-authors of the recent report, “Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.”  The employees are Jim Albert, lead project manager; Dr. Mat Makowski, senior biostatistician; and Kaitlyn Cross, senior biostatistician.

In its role as the statistical and data collection and coordination center, Emmes managed development of the statistical analysis plan and performed all data analysis. 

The recent NEJM publication focused on the immune response to the vaccine and whether the vaccine produced any adverse effects in two groups of older adults (56 to 70 years or ≥ 71 years). An earlier report in NEJM described findings from a Phase 1 trial of the mRNA-1273 candidate vaccine in adults ages 18 to 55 years old.

According to Albert, “It’s an honor to contribute to a study targeted on finding a vaccine for COVID-19 and to participate in writing two articles published in the prestigious New England Journal of Medicine during the same year.”

He added, “The whole world is watching the results of this and other vaccine trials, as we move closer to finding safe, effective ways to address this devastating disease.”

The first part of the Phase 1 trial, which began in March, tested 45 adults, while the subsequent portion enrolled 40 older adults during April and May.  As described in the Preliminary Report published in NEJM in July, this was a dose-escalation, open-label trial to assess the safety of the mRNA-1273 vaccine and its ability to induce an immune response.  Both papers concluded that adverse effects were predominantly mild or moderate in severity.  The side effects, such as fatigue, chills and headache, were found to be dose-dependent and were more common after the second immunization. According to this Sept. 29 report, volunteers receiving the 100 mcg dose produced a stronger antibody response than the 25 mcg dose. This observation supported the use of the 100 mcg dose vaccine in a Phase 3 trial of the candidate.

The trial was conducted at Kaiser Permanente Washington Health Research Institute in Seattle, the Emory University School of Medicine in Atlanta and the National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center in Bethesda, Maryland.  The vaccine was co-developed by researchers at the Vaccine Research Center, NIAID and at Moderna, Inc.  Moderna, Inc. manufactured and provided the vaccine candidate.

“COVID-19 is the latest in a long history of infectious disease research that Emmes has supported,” noted Dr. Christine Dingivan, Emmes president and chief executive officer.  “This includes H1N1 influenza, SARS, Ebola and Zika.  Our team has spent many long hours – nights and weekends – collecting and evaluating the statistical data,

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Data for Lilly’s bamlanivimab (LY-CoV555) in COVID-19 outpatients published in New England Journal of Medicine

INDIANAPOLIS, Oct. 28, 2020 /PRNewswire/ — The New England Journal of Medicine has published data from the monotherapy arms of BLAZE-1, a Phase 2 study assessing the efficacy and safety of Eli Lilly and Company’s (NYSE: LLY) bamlanivimab (LY-CoV555) – a neutralizing antibody – in the COVID-19 outpatient setting. This study focused on ambulatory COVID-19 patients being treated in the outpatient setting, whose symptoms did not require hospitalization at the time of enrollment. The publication, which can be found here, follows Lilly’s proof-of-concept data announcement for bamlanivimab as monotherapy in September 2020.

“The publication of these data in a peer-reviewed journal adds to the growing body of evidence for the potential utility for neutralizing antibodies as therapeutics for people recently diagnosed with mild to moderate COVID-19, particularly high-risk patients,” said Ajay Nirula, M.D., Ph.D., vice president of immunology at Lilly and co-first author of the study. “These data show bamlanivimab may be effective in treating COVID-19 by reducing viral load, symptoms and the risk of hospitalization in outpatients.”

“It is important to treat people with COVID-19 as soon as possible after diagnosis in order to forestall development of more severe disease,” said Peter Chen, M.D., director of Pulmonary and Critical Care Medicine at Cedars-Sinai and co-first author of the study. “Our findings indicate that neutralizing antibodies may have the potential to be useful in this early-stage intervention.”

These data were submitted as part of Lilly’s request for an emergency use authorization from the U.S. Food and Drug Administration for bamlanivimab in higher-risk patients who have been recently diagnosed with mild to moderate COVID-19.

About BLAZE-1

BLAZE-1 ( NCT04427501 ) is a randomized, double-blind, placebo-controlled Phase 2 study designed to assess the efficacy and safety of bamlanivimab alone or in combination with a second antibody for the treatment of symptomatic COVID-19 in the outpatient setting. To be eligible, patients were required to have mild or moderate symptoms of COVID-19 as well as a positive SARS-CoV-2 test based on a sample collected no more than three days prior to drug infusion.

The monotherapy arms of the trial enrolled mild to moderate recently diagnosed COVID-19 patients, studying three doses of bamlanivimab (700 mg, 2800 mg, and 7000 mg) versus placebo.

The primary outcome measure for the completed arms of the BLAZE-1 trial was change from baseline to day 11 in SARS-CoV-2 viral load. Additional endpoints include the percentage of participants who experience COVID-related hospitalization, ER visit or death from baseline through day 29, as well as safety.

The study is ongoing with additional treatment arms. Across all treatment arms, the trial will enroll over 800 participants.

Data from the BLAZE-1 study show bamlanivimab may be effective in treating COVID-19 by reducing viral load, symptoms and the risk of hospitalization in patients recently diagnosed with mild to moderate COVID-19. In the BLAZE-1 trial, rates and types of adverse events were similar between bamlanivimab and placebo, with the majority being mild to moderate in severity and with no drug-related serious adverse events reported thus

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Lose Weight With the 60 Day Food and Fitness Program & Journal

Keeping a weight loss journal can double your weightloss, studies show. Studies also now support the idea that old-fashioned calorie counting works the best for losing weight. Put these two weightloss tips to work for you with The 60 Day Food and Fitness Program & Journal by Brad Peterson, one of the most comprehensive weightloss journals available.

Why Keep a Weightloss Journal

Often people believe they are eating much less than they actually are. They don’t pay

attention to portion size and often estimate that they are eating many less calories than they actually consume. We kid ourselves that that little handful of chips or that cookie didn’t really count.

Keeping a weightloss journal allows you keep track of all the calories you actually eat throughout the day and stop estimating.

You might even see some interesting patterns, like empty calories spent on snacks or eating too much after dinner and before bedtime. You’ll see lots of ways you can save calories by keeping the journal.

What you’ll find in the 60 Day Food and Fitness Program & Journal

The 60 Day Food and Fitness Program & Journal focuses on keeping track of not only the foods you eat but the exercise you get to burn those calories and shrink those inches. There is great information provided in the front and back of the book relating to setting goals and how to reach them, with a page to write out your own goals. There are also charts on how many calories you burn with different activities and nutritional information on various foods, with a section just on fast food. There are also several pages of healthy recipes and a place to write in your own favorites.

The 60 Day Food and Fitness Program gives you a page to list all the foods you eat in a given day and helps you keep track of calories, fat and time of day that you ate. The opposite page is where you list your fitness activities, duration and calories burned. There is also a comment section to write down any notes and boxes to check off for each glass of water you drink. (There is a great article in the book about why drinking water is important to a weightloss program too!)

Once a week, there is a weight in page where you keep track of your weightloss and set your goals for the coming week. You can also keep track of your shrinking measurements. Other charts in the front of the book help you set up a fitness program and track your progress as well.

To lose a pound of fat, you need to burn 3,500 calories. No matter what weightloss plan or diet you adhere to, this fact won’t change. You can cut 3,500 calories from your diet – perhaps 500 calories a day – or you can do a combination of cutting calories and increasing exercise to burn those calories and you will lose weight. A weight loss journal can …

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Peer Reviewed Scientific Video Journal

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It contains original articles addressed to orthopaedic surgeons specializing in sports medicine, and to team physicians, athletic trainers, and physical therapists focusing on the causes and effects of injury or disease resulting from or impacted by athletic injury.

Il y eut une diminution modérée de la fréquence des infections invasives avant l’âge de deux ans avec une augmentation de la proportion des sérotypes 19A mais une augmentation de la fréquence des infections invasives à pneumocoque dans toutes les autres tranches d’âge.

You will discover how to take a history and examine a patient with lung illness to understand the pathophysiology, presentation the management and psychosocial influence of frequent lung ailments, and obtain knowledge of respiratory associated clinical expertise.…

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The Examined Life Journal

The Healthcare College is renowned for preparing its students to be world class physicians. At Point Lookout, Maryland, 50,000 prisoners passed through during the war and from 12,000 to 20,000 had been housed there at any provided time. Returning the PCP to his or her positon as the quarterback of patient care is very good medicine it means greater top quality, a a lot more satisfied patient, less frustrated physicians yet much lower total fees of care.

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This is the seventh year of the Walking Gallery of Healthcare. On a regional level, Dr. Bass served as president of the Alabama Thoracic Society from 1975 to 1976, later serving as a representative to the Healthcare Association of the State of Alabama Interspecialty Council.

L’obligation vaccinale ne garantit pas une augmentation de la couverture vaccinale et l’augmentation de la couverture vaccinale et aucun bénéfice de santé publique significatif ne peut être espéré pour certains de vaccins concernés par l’extension de l’obligation.

Family history (FH): listing of illnesses in the family members that might influence the patient. The fundamental science and clinical studies that are carried out at Stanford University cover a broad variety of regions in endocrinology, diabetes and metabolism.…

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American Journal Of Medicine, The

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Dr. Bass was active on a national level in shaping policy for the care of tuberculosis sufferers and health-related education. Trimbow simplifies therapy by offering just 1 inhaler, and a ‘measured’ dose. I’ve recently co-authored a book about precision medicine which highlights the need to have to combine evidence, patient preference, clinical history, genomics, and the encounter of other individuals to choose the right treatments.

When the paper is presented at the meeting, it occasionally only faintly resembles what was contained in the submitted abstract. Finnish students have an opportinity to join TASLO , local organization uniting Finnish medical students. Graduates are in open competition with college-leavers, and need to have to fulfil the same entrance requirements.

Minor misdemeanours will not necessarily stop you from entering the healthcare profession but you should declare these in your UCAS application and you will be sent the relevant forms to comprehensive if you are presented a place. It is also intended as an assurance to individuals and as a safeguard against charlatans that practice inadequate medicine for individual acquire.

Students have the opportunity to undertake analysis in a laboratory from a wide range of departments within the Medical Sciences Division. We are attending healthcare conferences exactly where frequently there isn’t a patient speaker on the dais or in the audience. I m a student completed my larger school from India.…

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Access Journal

The practice pledging this oath begans at the University of Wittenberg in Germany in 1508. No wonder the Times article quotes Dr. David J. Maron, the director of preventive cardiology at Stanford University School of Medicine, as saying This is fantastic”! This access to a very massive and diverse patient population enables you to obtain clinical experience from your very 1st term, with placements carefully selected to give you a broad and balanced clinical studying encounter.

Beyond the dissemination of the informational content of the articles that are reviewed, Journal Clubs serve as a reiteration and extension of the limitations portion of the report discussion. Penn Medicine Virtua Strategic Alliance Brings 1st Proton Therapy to South Jersey December 14, 2017 Cancer care in South Jersey is about to enter a new era.

Specialists such as John Bogle , Burton Malkiel , David Swenson and other folks have written influential books on the subject, using information from studies in economics (economic and behavioral). The branch of this science encompassing treatment by drugs, diet plan, workout, and other nonsurgical means.

At Point Lookout, Maryland, 50,000 prisoners passed by means of during the war and from 12,000 to 20,000 were housed there at any offered time. Returning the PCP to his or her positon as the quarterback of patient care is very good medicine it indicates greater good quality, a much more satisfied patient, less frustrated physicians however much lower total fees of care.

Traditional medicine has attempted to rehabilitate HRT, which implies that more girls are taking the drug, and a lot of of them will contract breast cancer as a outcome. Personally, I do believe that you would nevertheless be essential to full at least some 2 years of attendance at a US undergraduate school.…

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