The Alliance for Regenerative Medicine Announces Record Sector Financing in 2020

The regenerative medicine sector attracted $15.9 billion in financing through just the first three quarters of the year, shattering the previous record of $13.5 billion

Washington, DC – ( NewMediaWire ) – November 19, 2020 – Global financing for the regenerative medicine and advanced therapy sector set an annual record of $15.9 billion through just the first three quarters of 2020, according to  data  released today by the Alliance for Regenerative Medicine (ARM), the leading international advocacy organization dedicated to realizing the promise of regenerative medicines.

Despite the COVID-19 pandemic, financing for the cell, gene, and tissue-based therapies sector surpassed the previous record of $13.5 billion set during full-year 2018.

“There is strength across all types of investment and stages of the pipeline, from early-stage cell-based immuno-oncology to late-stage gene therapies,” said Janet Lambert, CEO of ARM. “The outlook for patients has never been brighter.”

Investors remain bullish about the promise of profound, durable, and possibly curative regenerative medicines to treat a range of diseases and disorders.

Public financing continues to drive the sector, through both IPOs ($2.8 billion YTD) and follow-on financings ($5.7 billion YTD). At $4.1 billion year-to-date, venture capital financing is also on track to surpass the previous record of $4.3 billion set in 2019.

“The rapid advancement of the science behind regenerative medicine makes this a very dynamic time for investors and a hopeful time for patients,” said Jason Rhodes, a partner at Atlas Venture. “The breadth of approaches now available — from CRISPR to CAR-Ts to lentiviruses and non-viral gene therapies — enables us to pick the right tool for the specific biology that we’re addressing.”

Highlights from ARM’s third-quarter 2020 data include:

Gene therapy financing was $3.5B in Q3 2020 and $12 billion YTD, up 178% and 114% from 2019 levels respectively; cell therapy financing reached $3 billion in Q3 2020 and $11 billion YTD, up 97% and 242%, respectively; tissue-based therapy financing was $226 million in Q3 2020 and $311 million YTD, up 11% and 311% respectively.*

At the end of Q3 2020, there were 1,109 regenerative medicine clinical trials ongoing worldwide – 373 in gene therapy, 492 in cell-based immuno-oncology, 202 in cell therapy, and 42 in tissue-based therapies.

Of the 1,109 clinical trials, 388 target more prevalent diseases, including prevalent cancers (159), cardiovascular disease (35), diseases of the central nervous system (33), infectious diseases including COVID-19 (38), and diabetes (17).

There are 97 ongoing Phase 3 clinical trials, with regulatory decisions expected in the coming months in the US and Europe for several product candidates across cell, gene, and tissue-based therapies; cell-based immuno-oncology now comprises more than half of the 418 Phase 1 trials.

There are 1,026 regenerative medicine and advanced therapy developers active globally, up from 1,001 in our previous report covering the first half of 2020. Of the current total, 536 are active in gene therapy, 641 are active in cell therapy, and 135 are active in tissue-based therapies.

* Some companies utilize multiple technology types, and financings for

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Synaptive Medical Announces Close of $17M Preferred Share Financing

Funding to advance Synaptive’s suite of fully automated cranial and spinal equipment and software designed to optimize personalized patient care

TORONTO, Oct. 29, 2020 (GLOBE NEWSWIRE) — Synaptive Medical, a leader in automation and robotics, announced today it has completed a sale of preferred equity totaling $17,000,000 USD. The investment was made by Sensegain Group, a leading asset management firm in China. Ms. Jing Yang, Board Member & Senior Partner of Sensegain, will join Synaptive’s Board of Directors.

Sensegain Group is headquartered in Beijing with multiple locations globally and has developed a strong partnership with industry leaders, as well as deep insights into sectors including TMT, Healthcare, and Advanced Manufacturing in China, United States, Canada, Israel, and other countries. Sensegain maintains a value investment principle and “Global + China” beliefs that help to maximize the value of portfolio companies and partners internationally. Synaptive management team worked tightly with Sensegain Group international team and the two parties are of great confidence that this investment will serve as a bright start of a long-term collaboration with each other.

This funding will enable Synaptive to further expand the availability of its suite of fully automated and integrated hardware and software products that enhance healthcare providers’ capabilities in diagnostic imaging, as well as surgical planning, navigation and visualization in the neurological and orthopedic spaces. Synaptive’s products have been uniquely designed to optimize workflow and enhance medical decision-making to improve patient outcomes.

In addition, Synaptive is announcing a new distribution partnership with Cicel Science and Technology Company, Ltd. of Beijing, for entry into the China market.

Marc Buntaine, CEO of Synaptive Medical, stated, “This investment is a testament to the confidence new investors have in Synaptive’s mission to provide state-of-the-art products that enable surgeons and healthcare professionals to provide safer patient-specific care in highly delicate cranial or spinal procedures for neurological disorders or injuries each year. With this financing, we are further committed to broadening the availability of our product offering to enter the greater China market with our new partner, Cicel.”

Cameron Piron, president and co-founder of Synaptive Medical, added, “We are excited to bring a new board member to our group with a strong background in finance and the China market.”

Synaptive offers products which provide world-class MRI cranial imaging, enhanced surgical planning, visualization both before and during surgery, and efficient data management throughout the clinical workflow, including medical informatics AI research. Synaptive’s products are modular and designed for seamless integration both within the Synaptive suite and with other products, so hospitals may purchase Synaptive offerings either individually or together, to best suit their needs.

About Synaptive Medical

Synaptive Medical Inc., a Toronto-based, global medical device and technology company solves surgical, imaging, and data challenges to improve the quality of human lives. Synaptive’s integrated suite of products – bridging MRI, surgical planning, navigation, and robotic visualization – delivers novel information with automated efficiency across all stages of clinical intervention.

About Sensegain Group

Sensegain Group is a leading asset management group headquartered

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Be Biopharma Launches with $52 Million Series A Financing to Advance B Cells as Medicines

— Creating new category of cellular medicines —

Be Biopharma (“Be Bio”), a leader in developing B cells as medicines, founded by Longwood Fund, David Rawlings, MD, and Richard James, PhD, today announced a $52 million Series A financing led by Atlas Venture and RA Capital Management and joined by Alta Partners, Longwood Fund and Takeda Ventures, Inc. The company plans to use this funding to precisely engineer B cells to treat a range of diseases, building on the pioneering work of Drs. Rawlings and James at Seattle Children’s Research Institute. B cells are prolific protein producers that can be collected from peripheral blood, have a programmable lifetime that could last decades, can target specific tissues, and have broad, customizable functionality.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201022005158/en/

David Steinberg, CEO, co-founder & director, Be Bio; general partner, Longwood Fund (Photo: Business Wire)

“Be Bio is capitalizing on the unique attributes of B cells to create a new category of medicine that is distinct from traditional cell or gene therapy,” said David Steinberg, Chief Executive Officer, co-founder and Director, Be Biopharma and General Partner, Longwood Fund. “B cells can be engineered to express a wide variety of proteins, have the potential to generate durable responses, and can be dose-titrated and administered multiple times without the need for toxic preconditioning. Moreover, the varied functions of B cells suggest that B cell medicines can address a range of conditions including autoimmune diseases, cancer, and monogenic disorders, as well as enhance the immune response to infectious pathogens. We believe Be Bio is at the forefront of a new approach to fighting disease.”

“B cells play a key role in combatting diseases by catalyzing humoral immunity – the arm of the immune system that manufactures large quantities of proteins to neutralize disease-causing pathogens and manipulate immune cell behavior,” said Be Biopharma co-founder David Rawlings, MD, Director, Center for Immunity and Immunotherapies, Seattle Children’s Research Institute and Professor of Pediatrics, University of Washington School of Medicine. “Today, this powerful part of the immune system is only passively and/or indirectly addressed therapeutically. Our ambition is to advance the field by building a new class of engineered B cell medicines that will provide direct control over the power of humoral immunity and help transform the prognosis for patients who currently have limited treatment options.”

In addition to Rawlings, James and Steinberg, Be Bio’s co-founders are Aleks Radovic-Moreno, PhD, President and Director, and Lea Hachigian, PhD, with Longwood Fund. The Board of Directors also includes Josh Resnick, MD, MBA, Managing Director, RA Capital Management; Jason Rhodes, Partner, Atlas Venture; and Dan Janney, MBA, Managing Partner, Alta Partners.

Be Biopharma’s Scientific Advisory Board consists of David Rawlings MD; Richard James, PhD, Principal Investigator, Seattle Children’s Research Institute and Associate Professor, Department of Pediatrics, University of Washington, as well as Frances Eun-Hyung Lee, MD, an Asthma, Allergy, and Immunology physician and researcher in Atlanta, GA; Shiv Pillai, MD, PhD, Professor, Harvard Medical School, Investigator

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