Low dose of the medicine intravenous immunoglobulin decreases the effect of dangerous toxins during severe infections

immunity
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During necrotizing soft tissue infections ordinary bacteria infect our body, spread rapidly and cause tissue death. Treatment with antibiotics is not sufficient and infected tissue needs to be removed through surgery. 22% of people who suffer from this disease need to amputate a limb and 18% do not survive.

A common cause of these infections is group A streptococcus. These bacteria form toxins that lead to overactivation of the body’s otherwise helpful immune cells, causing a so called “cytokine storm” which contributes to a severe course of the disease and the need of intensive care.

Recently, a study called INSTINCT was performed. In this study patients with necrotizing soft tissue infections were randomized to treatment with either intravenous immunoglobulin (IVIG) or placebo, in addition to other treatment. This study showed a trend towards better health after treatment with IVIG in the subgroup often caused by group A streptococcus, but no clear correlation during infections caused by other bacteria. However, the study used a lower dose than in previous studies: 25 g per day.

Bergsten et. al. tested blood samples from infected patients before and after treatment with IVIG, and found that treatment with IVIG leads to decreased effect of the toxins produced by the bacteria—even at the low dose of 25 g per day that was used in the INSTINCT study. Based on these results, the researchers suggest a new dosage regime of IVIG during these infections. It is still not proven that IVIG leads to better health during these devastating infections and the researchers suggest that the new dosage is tested in a controlled clinical trial of patients with necrotizing soft tissue infections caused by group A streptococcus.


IV immunoglobulin use up in interstitial lung disease


More information:
Helena Bergsten et al. Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections, Clinical Infectious Diseases (2020). DOI: 10.1093/cid/ciaa022
Provided by
Karolinska Institutet

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Low dose of the medicine intravenous immunoglobulin decreases the effect of dangerous toxins during severe infections (2020, October 28)
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Rampant Napoli give Atalanta dose of their own medicine

NAPLES, Italy (Reuters) – Napoli blasted four goals in a devastating 20-minute first half spell as they thumped Atalanta 4-1 in Serie A on Saturday, handing the visitors a taste of their own medicine.



Serie A - Napoli v Atalanta


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Serie A – Napoli v Atalanta

Free-scoring Atalanta, last season’s top-scorers with 98 goals, had netted 13 goals in winning their first three games but had no answer to Napoli’s attacks in an extraordinary first half.

Mexican forward Hirving Lozano, out of favour with coach Gennaro Gattuso last season, set Napoli on their way with two goals in four minutes.

The player known as “Chucky” tapped in from Giovanni Di Lorenzo’s cross in the 23rd minute and curled in the second after Dries Mertens pounced on a mix-up in the Atalanta midfield.

Matteo Politano fired the third on the half hour and Nigeria forward Victor Osimhen took advantage of more poor defending to score the fourth before the interval.

Napoli goalkeeper David Ospina’s kick upfield was misjudged by Cristian Romero and Osimhen, signed from Lille in the summer, chested the ball down and scored with a shot on the turn to net his first goal for his new club.

Romero partially made amends by setting up Atalanta’s consolation for substitute Sam Lammers in the 69th minute. The Argentine won possession, charged upfield and released Lammers who clipped his shot past Ospina.

Atalanta remained on nine points from four games, one ahead of Napoli.

Napoli have won all three of their games on the pitch, scoring 12 goals and conceding one.

However, Serie A’s disciplinary committee handed them a 3-0 defeat for failing to play a match against Juventus amid confusion over the COVID-19 rules and they also had a point deducted.

(Reporting by Brian Homewood, editing by Ed Osmond)

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How Asthma Responded to a Single Dose of Homeopathic Medicine – Antim Ars!

Homeopathic medicine often creates a mystique feeling about the action of drugs to novice homeopaths. The action of what is called the Constitutional Dose in homeopathy is often lauded by expert homeopaths and there is a great deal to learn from these experts.

Herewith I am explaining a case of asthma that responded extremely well to a single dose of homeopathic medicine- Antim ars.

Asthma is no doubt a crippling disorder that deteriorates the health of the person day by day. The severe wheezes might respond well to the inhalers prescribed by conventional medicine people. But this is certainly not the permanent solution to the problem; nonetheless, the patient has to deal with several side effects from these medications over the long term.

In order to avoid all these hassles, homeopaths often suggest people to go for homeopathic treatment right from the start so that it is comparatively easier to treat than after the heavy doses of steroid medications. Anyway, homeopathy will help at any stage if the homeopathic physician is capable of understanding the true nature of the disease and is able to apply his healing principle in the most positive way.

The case I was saying about was not different. The 22 years old male had come after a long battle with inhalers and other instant medication for about 10 years. He was breathless, the use of inhaler was increased in last 2 years, there were terrible wheezes, and he was unable to perform his day to day routine with ease these days.

The person still was tidier, had dressed well, was obviously chilly at the slightest cold air, wheezes were audible, he felt extremely weak, his breathlessness was aggravated on eating; so he preferred empty stomach, and there was productive cough. On these key notes, he was prescribed three doses of Antim ars 200 and told to take one immediately after going home and repeat the dose next day if he feels he still needs it.

The follow up was scheduled after 4 days. And within 3 days his asthma disappeared like he never had asthma before, with just 2 doses of Antim ars. This is not miracle cure, we all must remember. Homeopathy is not a miracle. If the homeopathic principles are applied in correct manner, with the right remedy, and in the right dosage, such miracle cures occur. Since then, the patient has had no bout of asthma whatsoever and if he develops any allergic symptoms or infections, simple homeopathic medicines help to take away the problem immediately without delay!

Certainly not in all cases, so fast results are achieved. Some cases do give us headaches, as to what is going wrong. But in most such cases, either the remedy selection or the dose goes wrong or some strong maintaining cause remains to be cleared like smoking. Homeopathic medicines selected properly however never disappoint us!

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A Healthy Dose of Medicine for the Soul

A large segment of the human population takes things way too seriously for their own good. The strange anomaly is that most people laugh at the wrong thing and fail to laugh at the right thing. This serious incongruity has robbed people of a healthy attitude towards life in general.

Those who take life too seriously are in danger of missing the great joys of living in a crazy world like ours. I am not sure about the scientific research but I would guess that for every sad moment it takes one hundred laughs to balance the books. Some people are about ninety-nine laughs short of a real sane moment.

I like the old English proverb that says, "Laugh and the whole world laughs with you, cry and you cry alone."

From my perspective, if you cannot laugh with someone you will not be able to cry with him or her and have it mean anything.

According to some medical advice, it takes more facial muscles and energy to frown than it does to smile. Of course, the only exercise some people have is frowning and who am I to take that away from them.

I am determined, no matter what, to exercise my right to smile and laugh and enjoy the world around me. I must confess that I get this attitude quite honestly.

My paternal grandfather was a Past Master in the area of ​​practical jokes. No amount of time was too much to spend preparing for one of his famous practical jokes. His favorite holiday was April 1 and began preparing for this holiday right after Christmas.

The fact that his practical jokes at times got him into trouble did not seem to affect him at all.

Once while in the hospital for an extended period he had somebody smuggle in to him a can of snuff. For some reason he liked chewing snuff. It is the most disgusting habit I know of on earth.

He no sooner received his smuggled goods then he began chewing it. If you know anything about chewing snuff, you know it is accompanied by a lot of spitting. As usual, his timing was impeccable. Just as the head nurse passed his door and looked in, he leaned over and spit in to the garbage can he had next to his bed. The nurse, not knowing about the chewing snuff, thought he was spitting blood and immediately went into emergency mode. Immediately my grandfather was rushed into the operating room and the surgeon and medical team were assembled.

My grandfather was very sick at the time. Some did not think he would get out of the hospital.

Just as they got him situated in the operating room he pulled from under his sheet his can of chewing snuff and smiled at them. The only person in the room that thought this was in any way amusing was my grandfather. The doctors were so angry with him that they refused to see him …

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