Scientists create living 3D-printed brain aneurysm from cells

The artificial aneurysm was created using a 3D printer and human cells (LLNL)
The artificial aneurysm was created using a 3D printer and human cells. (LLNL)

It sounds like something out of a horror film: scientists have created a living brain aneurysm using 3D-printed human brain cells and blood. 

Caused by a weakening in the artery walls, brain aneurysms are characterised by a “ballooning” or bulging of a blood vessel in the brain and can be fatal if they burst.

Researchers at Lawrence Livermore National Laboratory (LLNL) created a living, bioprinted aneurysm so that researchers could operate on it.

A team led by engineers William “Rick” Hynes and Monica Moya 3D-printed blood vessels with human cerebral cells. 

Read more: Signs and symptoms of a brain aneurysm

Hynes performed a repair procedure on the printed aneurysm and inserted a catheter into the blood vessel before tightly packing platinum coils inside the aneurysm sac.

The researchers introduced blood plasma into the aneurysm and observed the formation of a blood clot where the coils were located, cutting it off from fluid flow.

The researchers also were able to observe the “post-op” healing process of the cells within the vessels.

LLNL scientists said the platform, when combined with computer modelling, could allow researchers to design treatments specific to each patient.

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“While there are a lot of promising treatment options, some still have a long way to go,” said Moya, the project’s lead investigator. 

“Animal models aren’t necessarily the best way to try out these options, as they lack direct observation of treatment effects and have uncontrollable aneurysm geometries.

“Having this robust, human in vitro testing platform could help facilitate new treatments. If we can replicate aneurysms as much as we need to with these devices, we might help accelerate some of these products into the clinic and essentially provide patients with better treatment options.”

Read more: Ketamine-like spray not given green light by NHS

The researchers believe the new testing platform could lead to more personalised treatments for people with brain aneurysms.

Hynes said: “We looked at the problem and thought that if we could pair computational modelling and experimental approaches, maybe we could come up with a more deterministic method of treating aneurysms or selecting treatments that could best serve the patient.

“Now we can start to build the framework of a personalised model that a surgical practitioner could use to determine the best method for treating an aneurysm.”

Watch: How to stimulate brain health during lockdown

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DentaQuest Partnership and 120 Industry Leaders Create New Framework For More Sustainable Oral Health System

Three Domain Framework is the future of dentistry

Boston, Oct. 26, 2020 (GLOBE NEWSWIRE) — Even as the COVID-19 pandemic exacerbates the nation’s broken oral health care system, it has created an opportunity for the industry to move toward a new, more sustainable model centered around the patient, primary care and prevention. The DentaQuest Partnership for Oral Health Advancement released a report today — based on the work of the Community Oral Health Transformation Initiative learning community — that establishes a primary care-like structure for oral health care delivery, facilitates value-based payment models and enables patients to invest in their own oral health.

120 of the industry’s most prominent organizations and leaders contributed to the development of the Three Domain Framework, which lays out a clear path for providers and practices to expand access to care, improve health outcomes and reduce the cost burdens associated with poor quality of life due to oral disease.

The framework gives patients and dental and medical providers the freedom to collaborate on treatment plans that work best for a given situation within the context of overall health. And it emphasizes patient and provider safety while addressing critical gaps in both patients’ access to care and providers’ financial viability.  

“Oral health is directly linked to overall health, but our current system doesn’t reflect that reality,” said Dr. Sean Boynes, vice president of health improvement for the DentaQuest Partnership for Oral Health Advancement. “And COVID-19 has shined a bright spotlight on this flaw. The Three Domain Framework outlines a new approach for oral health — one that focuses on prevention and healthy outcomes, facilitates value-based payment models, and will help address deep disparities in care and access. We are grateful to the many contributors who are working together to put our oral health system on a new and better path. This is the future of dentistry.”

The three domains can be adopted in any order, meaning the care team can determine where to begin. Providers can safely begin shifting their models of dentistry by starting in a domain that supports their unique needs and those of their patients. 

Domain One: Advancements in Teledentistry

The pandemic has increased interest in and utilization of teledentistry, but widespread adoption requires defining new treatment codes and rethinking the flow of care for a variety of dental visits. Domain One focuses on the identification, development and adoption of telehealth strategies and builds an accessible evidence-based virtual delivery approach specific to oral health that can enhance disease prevention and whole-person health.

Domain Two: Prioritization of Minimally Invasive Care

The pandemic also sparked interest in Minimally Invasive Care (MIC), as providers sought treatment methods, like sealants and silver diamine fluoride, that limit aerosols and the spread of COVID-19. MIC can reverse or slow early disease stages using a program of anticipatory guidance and collaborative decision-making with patients. Domain Two prioritizes the use of MIC for oral health management and maintenance.

Domain Three: Integration and Personalization of Oral Care Delivery

Domain Three

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Hylete Aims to Create the Next Big Fitness Brand



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A bright green button on a keyboard that says Equity Crowdfunding. companies to invest in

Hylete is a fitness lifestyle brand, with a wide assortment of apparel items for men and women. The company is also raising capital through an equity crowdfunding campaign on StartEngine. The minimum investment for Hylete is only $500.



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The co-founders of the company include Ron Wilson and Matthew Paulson, who both had high-level positions at companies like Jaco Clothing and Gathering Storm before starting the company. In 2012, they saw an opportunity to develop a better training short for those who were serious about fitness.

The reception was strong and the co-founders quickly moved into other categories like shirts, pants, hoodies, backpacks and cross-training shoes.

Background on the Company

One of the keys to the success of Hylete is its focus on personalization. This is certainly important for fitness requirements. To this end, the company has created a quiz on its website to determine the best fit for its clothing line. For example, there are 14 distinct styles for shorts.

Hylete has also spent much time cultivating an engaged community (there are over 81,000 followers on Instagram and the company’s products have gotten over 51,000 five-star reviews). Because of this, the company has received valuable feedback to improve its products.

Here are just a few of the company’s offerings:

  • Incline shorts: This uses a stretch woven fabric that has enough room for the hips and thighs, which means higher impact movement.
  • Urban joggers: This item strives for a both warmth and breathability. Some of the features include a drawstring waistband and an internal fleece fabric.
  • Altium sports bra: This has an X-strap for better support and comfort but does not grind into a woman’s shoulders.
  • Circuit II cross-training shoe: These allows you to choose between three types of insoles.
  • Nimbus tights: This is a legging that is meant to complement a person’s hips and legs.

What about the traction for the company? Well, the company has definitely shown strong growth. According to the investor materials, the compound annual growth rate is over 70% and last year’s sales hit $12.6 million. There are more than 300,000 customers and over 30,000 are certified fitness experts, who have provided content on the Hylete blog and social channels.

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Bottom Line On Hylete

The equity crowdfunding capital raise has gone quite well. So far, the company has received commitments for more than $734,000 from 974 investors (the valuation has been set at $44.8 million). Yes, it seems that the company’s own community has been essential for this success.

The investment also comes with several perks. That is, there is 50% off all regular-priced products and 10% discounts on clearance locker items. Then there is also free ground shipping for U.S. orders and one Hylete rewards point for each dollar invested.

But of course, as is the

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