Lobe Sciences Announces Launch of Preclinical Study in Collaboration with the University of Miami Miller School of Medicine

(MENAFN – Newsfile Corp) Lobe Sciences Announces Launch of Preclinical Study in Collaboration with the University of Miami Miller School of Medicine

Vancouver, British Columbia–(Newsfile Corp. – November 30, 2020) – Lobe Sciences Ltd. (CSE: LOBE) (OTC Pink: GTSIF) (” Lobe ” or the ” Company “) is pleased to announce the launch of preclinical research studies using psilocybin and N-Acetylcysteine (” NAC “) for the treatment of mild traumatic brain injury/concussion (” mTBI “) with post-traumatic stress disorder (” PTSD “). The study is in collaboration with a multidisciplinary team of scientists and physicians at the University of Miami Miller School of Medicine under the lead of Michael E. Hoffer, M.D., professor of otolaryngology and neurological surgery.

NAC has been shown to be safe and efficacious in a phase I human clinical study in treating military personnel who had suffered mTBI. The initial research focus is to demonstrate the safety and efficacy of the combination of psilocybin and NAC using broadly accepted rodent models. Final results are expected in 2021. Once this is established, more specific work can examine dose response, medicine uptake, and medicine levels. The research team at the Miller School of Medicine has conducted prior studies involving NAC with mTBI and has a license from the United States Drug Enforcement Administration to conduct research using Schedule I controlled substances, which includes psilocybin.

The Miller School of Medicine is an internationally recognized leader in medical research, ranked No. 39 among the top medical schools in the nation by Blue Ridge Institute for Medical Research. In 2019, the medical school submitted 1,968 research proposals and was awarded $149 million in research funding from the National Institutes of Health (NIH).

Advances in neuro-diagnostic assessment have revealed mild traumatic brain injury (concussion) is more common than previously thought and potentially associated with a host of negative health outcomes. The Centers for Disease Control (” CDC “) estimates that there are 3 million emergency room visits and over 230,000 hospitalizations due to TBI in any given year in the United States alone. Also, at the same time there are 5.3 million Americans living with the effects of mTBI (a 53% increase over ten years ago). The World Health Organization calls traumatic brain injury a “silent epidemic” that affects over 70 million individuals across the world. The United States Department of Defense estimates that over 345,000 individuals are affected by mTBI and that 20% of all service members who deploy suffer mTBI. mTBI and PTSD are significant health care issues that often co-occur and impact each other.

Dr. Hoffer, the principal investigator on the study, said, “This a very important extension of our work with NAC and other medicines to identify new treatments for mTBI and PTSD. We are hopeful that this new combination of psilocybin with NAC will lead us to better solutions for those suffering from mTBI and/or PTSD.”

Maghsoud Dariani, Chief Science Officer of Lobe said, “We are very excited to begin the preclinical studies in collaboration with Dr.

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Gain Therapeutics and University of Maryland School of Medicine Announce Research Collaboration

BETHESDA, Md. and BALTIMORE, Nov. 30, 2020 (GLOBE NEWSWIRE) — Gain Therapeutics, Inc. (“Gain”), today announced a research collaboration with the University of Maryland School of Medicine (UMSOM), to investigate Gain’s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease (nGD) and Parkinson’s disease (PD). STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes. These small molecule drug candidates are designed to cross the blood brain barrier and penetrate other hard to treat organs such as bone and cartilage, stabilize the effective enzyme to restore function and reduce toxic substrate. Research will be led by Ricardo A. Feldman, Ph.D., Associate Professor, of Microbiology and Immunology in UMSOM.

Under the terms of the collaboration, UMSOM will investigate Gain’s STAR candidates in macrophage and neuronal models of nGD and GBA-associated PD. These diseases are characterized by mutations in the GBA gene, where misfolding of the enzyme encoded by GBA (beta-glucocerebrosidase (GCase)) interferes with its normal transport to the lysosome. The research program will aim to further elucidate the mechanism of action of Gain’s STAR candidates by studying their effect on GCase, including GCase’s enzyme activity and transport to the lysosome. Additionally, other effects such as prevention of alpha-synuclein aggregation in PD dopaminergic neurons will be evaluated.

“We are exceedingly proud to be advancing our work in nGD and Parkinson’s in close collaboration with the University of Maryland School of Medicine,” said Eric Richman, Chief Executive Officer at Gain. “The expertise and experience of UMSOM and Dr. Feldman will be instrumental as we work to further validate the exciting potential of Gain’s STAR candidate for these devastating diseases. I am confident these foundational studies will bring us closer to a potential new treatment option for those with these disorders.”

Dr. Feldman added, “Our laboratory has used human induced pluripotent stem cell (iPSC) models of GD and GBA-associated PD to uncover the molecular mechanisms leading to these diseases. We have also developed very sensitive assays to evaluate the therapeutic efficacy of small molecules in reversing the phenotypic abnormalities caused by mutant GBA in the cell types affected by these diseases, including macrophages and neuronal cells. I have been impressed by Gain’s initial results evaluating the potential of STARs in correcting enzyme misfolding and restoring function, and look forward to working with Gain’s team to further advance its program to treat these diseases.”

Gain and UMSOM intend to report initial data from the collaboration in the first half of 2021.

About Gain Therapeutics, Inc.
Gain Therapeutics is redefining drug discovery with its SEE-Tx™ target identification platform. By identifying and optimizing allosteric binding sites that have never before been targeted, Gain is unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding. Gain was originally established in 2017 with the support of its founders and institutional investors such as TiVenture, 3B Future Health Fund (previously known as Helsinn Investment Fund) and VitaTech. It has been awarded funding support from The Michael J. Fox Foundation for

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Sandoz ships first medicine in collaboration with Civica Rx to supply US hospitals

PRINCETON, N.J., Nov. 2, 2020 /PRNewswire/ — Sandoz Inc. today announced that it has shipped pantoprazole sodium for injection, 40 mg to Civica Rx to supply the hospitals it serves as part of a multiyear collaboration to help reduce supply shortages, with several other medicines on the way before the end of the year.

Pantoprazole is the first Sandoz medicine to ship to Civica since entering into the agreement in July. It is a proton pump inhibitor indicated in adults for the short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD), associated with a history of erosive esophagitis1

Sandoz previously announced it will supply six injectable medicines under the Civica private label to its 1,200 US hospitals. The agreement is being expanded to include an additional medicine to regulate blood pressure, which is frequently used to treat COVID-19 patients in hospitals.

“Our collaboration with Civica is providing certainty for hospitals, doctors and patients who are too often frustrated by shortages of medicines. This is especially important as healthcare providers continue to manage the COVID-19 pandemic,” said Carol Lynch, President, Sandoz Inc. “We are committed to ensuring our medicines are there for the patients who need them when they need them.”

Civica, a non-profit, was founded in 2018 by leading US hospital systems concerned about generic drug shortages and philanthropic organizations passionate about improving healthcare. To date, more than 50 health systems are Civica members, representing more than 1,200 US hospitals and approximately 30 percent of all licensed US hospital beds including acute care. 

“Within a year since our first medication was administered in a hospital ICU, we’ve been able to help millions of patients,” said Martin VanTrieste, president and CEO of Civica. “With Sandoz, we look forward to helping millions more by providing critical medicines that have often been in short supply.”

INDICATIONS AND USAGE

Pantoprazole sodium is a proton pump inhibitor (PPI) indicated in adults for the following:

  • Short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) associated with a history of Erosive Esophagitis (EE).
  • Pathological hypersecretion conditions including Zollinger-Ellison (ZE) Syndrome.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

  • Patients with a known hypersensitivity to any component of the formulation or to substituted benzimidazoles.
  • Patients receiving rilpivirine-containing products.

WARNINGS AND PRECAUTIONS

  • Gastric Malignancy: In adults, symptomatic response to therapy with pantoprazole sodium for injection does not preclude the presence of gastric malignancy. Consider additional follow-up and diagnostic testing.
  • Hypersensitivity and Severe Skin Reactions: Anaphylaxis and other serious reactions such as erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis (TEN) have been reported.
  • Injection Site Reactions: Thrombophlebitis is associated with the administration of intravenous pantoprazole.
  • Potential Exacerbation of Zinc Deficiency: Consider zinc supplementation in patients who are prone to zinc deficiency. Caution should be used when other EDTA containing products are also co-administered intravenously.
  • Acute Interstitial Nephritis: Observed in patients taking PPIs.
  • Clostridium difficile-Associated Diarrhea: PPI therapy may be associated with increased risk.
  • Bone Fracture: Long-term and multiple daily dose PPI therapy may
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Addex Receives Additional $2.8 million from Indivior and Extends GABAB PAM Research Collaboration

Geneva, Switzerland, November 2, 2020 – Addex Therapeutics Ltd (SIX and Nasdaq: ADXN), a leading company pioneering allosteric modulation-based drug discovery and development, today announced that the research term of the agreement signed with Indivior PLC (LON: INDV) in January 2018 has been extended until June 30, 2021. The collaboration with Indivior covers the discovery of novel oral gamma-aminobutyric acid receptor subtype B (GABAB) positive allosteric modulator (PAM) compounds as potential therapies for multiple disease areas. As part of the amended agreement, Indivior has agreed to pay Addex $2.8 million in research funding and expand the therapeutic areas where Addex has exclusivity to develop retained compounds.

“The extension of our research collaboration and the additional funding from Indivior is a clear recognition of the potential of our allosteric modulator discovery platform and the significant achievements of our drug discovery team,” said Tim Dyer, CEO of Addex. “Indivior is a world leader in the development of addiction medication and strongly committed to GABAB PAM as a potential treatment for addiction including alcohol use disorder.”

“Although 200 health conditions have been linked to harmful alcohol use,1 there are few pharmacotherapies for alcohol use disorder (AUD) – their efficacy and uptake in clinical practice are limited, and patient acceptance is minimal. We are, therefore, very pleased to expand our partnership with Addex Therapeutics to discover and profile new potent and selective GABAB PAMs and provide a new class of medications that has the potential to achieve therapeutic benefits in patients suffering from AUD,” said Christian Heidbreder, Chief Scientific Officer of Indivior.

“Due to the extensive validation of GABAB activation with baclofen, we believe a novel, orally available GABAB PAM could provide significant benefits to patients in many therapeutics areas,” said Jean-Philippe Rocher, Co-Head of Discovery. “We have advanced multiple novel chemical series’ to late stages of lead optimization and we look forward to rapidly delivering first-in-class compounds for Indivior to advance into clinical development.”

Under the terms of the original agreement signed with Indivior in January 2018, Addex received a $5 million upfront payment and has since received $5.6 million research funding. Addex is eligible to receive up to $330 million of development, regulatory and commercialization milestones as well as tiered royalties up to teen double-digit. In addition, Addex has the right to retain certain compounds and pursue their development for reserved indications outside addiction, including for the treatment of Charcot-Marie-Tooth type 1a (CMT1A) neuropathy, a rare inherited disorder that affects peripheral nerves. Addex has discovered novel GABAB PAMs and has made significant progress in optimization of potential drug candidates. Addex expects to enter clinical candidate selection phase by end of 2020 and deliver drug candidates for IND enabling studies by the end of 2021 for both Indivior and for its in-house CMT1A program.

About GABAB Activation with PAM

Activation of the GABAB receptor, a Family C class of GPCR, is clinically and commercially validated by the generic GABAB

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IAEA and French Society of Nuclear Medicine Sign Practical Arrangements to Promote Collaboration in Nuclear Medicine

The PAs provide a framework for collaboration in the area of capacity building for nuclear medicine and molecular imaging, or any allied disciplines, particularly for professionals from French-speaking countries. (Photo: D. Calma/IAEA)

The finalization and signing of these PAs are the latest development in a shared history of successful collaboration between the Agency and the SFMN which stretches back more than a decade.

In recent years the SFMN has invited IAEA experts to participate in its Annual Meetings and helped to host and place IAEA fellows into clinical and scientific research centres across France. In particular, the SFMN trained five African fellows in 2017, through the National Institute for Nuclear Science and Technology (INSTN) platform.

Additionally, the SFMN has supported the IAEA’s technical cooperation programme through the identification of French-speaking experts and cost-free experts, who in turn have supported Africa Member States as they draft and subsequently adopt clinical protocols for expanding the scope of nuclear medicine services and capabilities.

The Practical Arrangements will provide new opportunities to not only strengthen nuclear medicine capacities in the region, but to establish new collaborative avenues in other, related support areas for nuclear medicine, such as mentorship, networking, building remote or virtual training systems, the use and development of software platforms and data management.

Source Article

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Ultragenyx and Solid Biosciences Announce Strategic Collaboration to Develop and Commercialize New Gene Therapies for Duchenne Muscular Dystrophy

Collaboration combines Solid’s differentiated microdystrophin construct and Ultragenyx’s HeLa PCL manufacturing platform for use with AAV8 and variants

Solid receives $40 million upfront via equity investment at a premium; up to $255 million in milestones plus royalty payments

Solid retains exclusive rights to all other uses of its microdystrophins, including its existing SGT-001 program

NOVATO, Calif. and CAMBRIDGE, Mass., Oct. 23, 2020 (GLOBE NEWSWIRE) — Ultragenyx Pharmaceutical Inc. (Nasdaq: RARE), a biopharmaceutical company focused on the development and commercialization of novel products for serious rare and ultra-rare diseases, and Solid Biosciences Inc. (Nasdaq: SLDB), a life sciences company focused on advancing meaningful therapies for Duchenne muscular dystrophy (Duchenne), today announced a strategic collaboration and license agreement to focus on the development and commercialization of new gene therapies for Duchenne. The parties will collaborate to develop products that combine Solid’s differentiated microdystrophin construct, Ultragenyx’s HeLa producer cell line (PCL) manufacturing platform, and AAV8 variants. The collaboration also brings together Solid’s expertise in muscle biology and Ultragenyx’s expertise in bringing novel therapies to patients with rare diseases.

Under the terms of the collaboration, Solid granted Ultragenyx an exclusive license for any pharmaceutical product that expresses Solid’s proprietary microdystrophin construct from AAV8 and variants thereof in clade E for use in the treatment of Duchenne and other diseases resulting from lack of functional dystrophin, including Becker muscular dystrophy. Ultragenyx has made a $40 million investment in Solid and has agreed to pay up to $255 million in cumulative milestone payments per product upon achievement of specified milestone events, and tiered royalties on worldwide net sales at low double digit to mid-teens percentages. Upon achievement of proof-of-concept, Solid has the right to opt-in to co-fund collaboration programs in return for participation in a profit share or increased royalty payments.

“We believe that Solid’s microdystrophin is best-in-class with its unique neuronal nitric oxide synthase binding domain,” said Emil D. Kakkis, MD, PhD, Chief Executive Officer and President of Ultragenyx. “By using an AAV8 variant validated in prior human and other studies combined with our scalable, efficient HeLa producer cell line platform, we believe we can leverage our mutual strengths to develop a high-quality AAV-based treatment alternative for Duchenne.”

“Ultragenyx has a demonstrated track record of success in developing and commercializing innovative therapies for rare diseases,” said Ilan Ganot, Co-Founder, President and Chief Executive Officer at Solid Biosciences. “We believe it is the partner of choice for exploring new gene therapy opportunities for patients with Duchenne.”

Solid’s proprietary microdystrophin construct has exhibited functional benefit in preclinical models. In preclinical studies, animals expressing a microdystrophin capable of restoring neuronal nitric oxide synthase (nNOS) resisted fatigue better than those expressing a microdystrophin that does not. Patients dosed with Solid’s proprietary microdystrophin construct at the 2E14 vg/kg dose in Solid’s ongoing IGNITE DMD clinical trial have also preliminarily demonstrated nNOS activity and function, further validating these preclinical results. Solid expects to dose the next patient in the IGNITE DMD clinical

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Contakt World Enters 3-Year Strategic Collaboration with Satcher Health Leadership Institute at Morehouse School of Medicine

Partnership to Improve Health Equity, Reduce Health Disparities, and Improve Community Health Amid COVID-19 Pandemic

OCEANSIDE, CA / ACCESSWIRE / October 22, 2020 / Contakt LLC, subsidiary of Contakt World Technologies Corp. (“Contakt World”), a technology company modernizing the contact tracing process, today announced a strategic partnership with the Satcher Health Leadership Institute (SHLI) at Morehouse School of Medicine to provide COVID-19 resources and the Contakt World Platform for digital contact tracing to support communities hardest hit by the pandemic. Over three years, Contakt will assist SHLI and local, state, and national health agency partners to identify, monitor and support marginalized populations who are at heightened risk of exposure and complications from coronavirus. The program is expected to reach all fifty United States and territories, as well as tribal nations disproportionately impacted by the COVID-19 pandemic.

SHLI is a leading academic institute within Morehouse School of Medicine that prioritizes research, training, and leadership development programs to eliminate inequities that prevent individuals from achieving optimal health. SHLI is leading several national projects to mitigate the impact of COVID-19 on vulnerable and underserved communities, including the the National Infrastructure for Mitigating the Impact of COVID-19 funded by the U.S. Department of Health and Human Services (HHS), and the Health Equity Tracker project with Google.org, CDC Foundation, and Gilead Sciences (NASDAQ: GILD). Both projects aim to understand the root cause of the disproportionate spread of COVID-19 and other co-morbidities in minority communities and provide accessible health solutions. As part of the 3-year initial term between Contakt World and SHLI – Contakt World intends to obtain United States entitlements to use the Google-Apple Exposure Notification System (“GAEN”), while adding functionality across an array of tools for consumers, health agencies, and businesses to improve health agency reach to marginalized populations who may not have access to the latest smartphones using GAEN.

“We are honored to partner with SHLI on this project to improve the overall health of all communities and provide the right tools and resources to communities fighting the COVID-19 pandemic,” said Justin Beck, Chief Executive Officer of Contakt World. “Any system designed for truly scaled digital contact tracing must be deliberately accessible and reach people where they are. We look forward to working with SHLI to ensure that no person is denied critical health information due to digital divides, language barriers or other limitations of trust or technology.”

Contakt World will enable any community working with SHLI with technologies to support their efforts to serve high risk areas. The Contakt World Platform will initially be available through the SHLI collaboration in Albany, GA., South Florida, New Orleans, LA., Moore County, TX., Alaska, Navajo Nation with plans to expand to all 50 states and territories within the next three years or earlier by request.

“COVID-19 has exposed and exacerbated health inequities that have existed long before the pandemic started earlier this year,” said Daniel E. Dawes, Director of the Satcher Health Leadership Institute at Morehouse School of Medicine and author of The Political

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Roche announces collaboration with Atea Pharmaceuticals to develop a potential oral treatment for COVID-19 patients

  • Roche and Atea partner to jointly develop AT-527, an orally administered direct-acting antiviral (DAA) currently in Phase 2 clinical trials

  • AT-527 has the potential to be the first novel oral antiviral to treat COVID-19 patients outside the hospital setting as well as in the hospital and may also be used in post-exposure prophylactic settings

  • Oral, small-molecule DAAs for COVID-19 patients allow for large-scale manufacturing and facilitate broad patient access

  • If approved, Atea will distribute AT-527 in the United States and Roche will be responsible for global manufacturing and distribution outside the United States

Basel, 22 October 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) and Atea Pharmaceuticals, Inc. announced today that they are joining forces in the fight against COVID-19 to develop, manufacture and distribute AT-527, Atea’s investigational oral direct-acting antiviral, to people around the globe. AT-527 acts by blocking the viral RNA polymerase enzyme needed for viral replication, and is currently being studied in a Phase 2 clinical trial for hospitalised patients with moderate COVID-19. A Phase 3 clinical trial, expected to start in Q1 2021, will explore the potential use in patients outside of the hospital setting. In addition, AT-527 may be developed for post-exposure prophylactic settings.

AT-527, while being a potential oral treatment option for hospitalised patients, also holds the potential to be the first oral treatment option for COVID-19 patients that are not hospitalised.  Additionally, the manufacturing process of small-molecule DAAs allows the ability to produce large quantities of a much needed treatment. If successful, AT-527 could help treat patients early, reduce the progression of the infection, and contribute to decreasing the overall burden on health systems.

The collaboration aims to accelerate the clinical development and manufacturing of AT-527, to investigate its safety and efficacy, and to provide this potential treatment option to patients around the world as quickly as possible. If AT-527 proves safe and effective in clinical trials and regulatory approvals are granted, Atea will be responsible for distributing this treatment option in the U.S, with the option to request Genentech’s support, and Roche will be responsible for distribution outside the United States.

“The ongoing complexities of COVID-19 require multiple lines of defence. By joining forces with Atea, we hope to offer an additional treatment option for hospitalised and non-hospitalised COVID-19 patients, and to ease the burden on hospitals during a global pandemic.” said Bill Anderson, Chief Executive Officer of Roche Pharmaceuticals. “In jointly developing and manufacturing AT-527 at scale, we seek to make this treatment option available to as many people around the world as we possibly can.”

“Roche shares our passion for delivering innovative new medicines to address great unmet medical needs. The COVID-19 pandemic has highlighted the urgent need for a novel, oral antiviral to treat this highly infectious and often deadly virus,” said Jean-Pierre Sommadossi, Ph.D., Chief Executive Officer and Founder of Atea Pharmaceuticals. “AT-527 is expected to be ideally suited to combat COVID-19 as it inhibits viral replication by interfering with viral RNA polymerase, a key component in the

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sbe Announces Exclusive Collaboration with Celeb-Favorite DOGPOUND Gym and Fitness Services | News

NEW YORK, Oct. 21, 2020 /PRNewswire/ — sbe, the leading international hospitality group that develops, manages and operates award-winning brands, today announced a multi-faceted global partnership with leading luxury wellness and lifestyle brand, DOGPOUND. The initial rollout will commence on October 21st, 2020 and will be highlighted by the launching of a customized fitness program at renowned sbe properties SLS South Beach and SLS Brickell.  This will be closely followed by the addition of Mondrian Doha and other sbe properties as the partnership expands internationally.

A favorite among celebrities and supermodels from around the world, this will be the first hotel partnership for DOGPOUND, providing sbe guests with exclusive access to a dynamic array of virtual training sessions, previously only available to DOGPOUND clients. In the initial launch phase, DOGPOUND’s expert fitness trainers will coach sbe guests through virtual one-on-one fitness training sessions in the comfort of their sbe hotel rooms. Tailored to each guest’s fitness level and equipment access, the DOGPOUND trainers offer a bespoke approach to training that will include key stretches, bodyweight moves, and an overall, well-rounded fitness experience.

We’ve noticed a significant rise in requests for health and wellness services at sbe properties and sought out a partner that aligned with our consumer’s luxury lifestyle and could provide the best-of-the-best,” said sbe Chief Business Officer Philippe Zrihen. “DOGPOUND has a cult following as one of the most innovative and trendsetting companies in the lifestyle fitness space. As our guests look for new ways to stay healthy, this partnership provides them with remarkable, results-driven personal training and a wellness-focused community at the touch of a button.”

In the coming year, sbe and DOGPOUND will expand the virtual workout program to additional properties with potential for even more unique fitness opportunities or additional avenues of collaboration.

“This is a first for our company and we jumped at the chance to bring our private training sessions and nutritional programs to global travelers through a partnership with sbe, a luxury brand we’ve long admired,” says DOGPOUND Founder and CEO, Kirk Myers. “Since each workout is catered to the individual, no session is the same, meaning sbe guests can return to their hotel room day after day, week after week, for a completely new experience. We’re providing access to some of DOGPOUND’s top trainers so sbe guests can CRUSH IT from anywhere in the world.”

sbe’s collaboration with DOGPOUND further advances the hospitality group’s health and wellness platform in response to growing interests among lifestyle consumers – 80 percent of whom are more engaged with their health than they were prior to the pandemic, according to a recent survey by Slingshot. Providing a full-service approach to wellness, sbe already partners with leading fitness companies Therabody to provide deep muscle therapy amenities, and Goldsheep for branded activewear, with more collaborations expected to be announced.

“Wellness is no longer a nice-to-have when guests are picking their preferred hotel, it is a must-have. DOGPOUND is a natural complement

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ImmunoGen and Huadong Medicine Announce Strategic Collaboration to Develop and Commercialize Mirvetuximab Soravtansine in Greater China

Partnership Accelerates Development Path for Mirvetuximab in Greater China and Expands Huadong Medicine’s Oncology Portfolio with Innovative ADC

Combines ImmunoGen’s Lead Clinical Program with Huadong’s Regional Oncology Expertise

ImmunoGen to Receive $40 Million Upfront Payment and is Eligible to Receive Up to $265 Million in Potential Development, Regulatory, and Commercial Milestone Payments

ImmunoGen, Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, and Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., a wholly-owned subsidiary of Huadong Medicine Co., Ltd., today announced that the companies have entered into an exclusive collaboration to develop and commercialize mirvetuximab soravtansine in mainland China, Hong Kong, Macau, and Taiwan (Greater China). ImmunoGen will retain all rights to mirvetuximab in the rest of the world.

This collaboration provides ImmunoGen with access to the second largest pharmaceutical market in the world via Huadong Medicine’s development, regulatory, and commercial capabilities, while supporting Huadong Medicine’s growth strategy to build a deep portfolio of oncology, endocrinology, and autoimmunology candidates. Mirvetuximab adds a compelling late-stage oncology asset to Huadong Medicine’s portfolio.

“With extensive regional experience, the right development and regulatory capabilities, and access to a deep local network of hospitals and clinics across Greater China, Huadong Medicine is an ideal partner for us,” said Mark Enyedy, ImmunoGen’s President and Chief Executive Officer. “This collaboration reflects mirvetuximab’s potential to deliver meaningful value to ovarian cancer patients as well as our ability to translate our work in ADCs into long-term relationships that create sustainable value for ImmunoGen and our partners. We look forward to working closely with Huadong Medicine to develop and commercialize mirvetuximab in Greater China as we advance the mirvetuximab program and prepare for the first potential commercial launch in the United States in 2022.”

“ImmunoGen is a leader in the development of ADCs for the treatment of cancer and this partnership provides us with a late-stage asset that will enable us to further expand our pipeline of innovative oncology programs,” said Liang Lu, Chairman of Huadong Medicine. “The compelling clinical data generated to date highlights mirvetuximab’s potential to be a promising therapy for an extremely difficult to treat disease and we look forward to beginning its development as we seek to meet the growing needs of ovarian cancer patients in Greater China.”

Under the terms of the agreement, ImmunoGen will receive an upfront payment of $40 million and is eligible to receive additional milestone payments of up to $265 million as certain development, regulatory, and commercial objectives are achieved. ImmunoGen is also eligible to receive low double digit to high teen royalties as a percentage of mirvetuximab commercial sales by Huadong Medicine in Greater China.

Huadong Medicine will be responsible for the development as well as potential regulatory submissions and commercialization of mirvetuximab in Greater China pursuant to input from a joint steering committee comprised of individuals from both companies. Huadong Medicine will also have the opportunity to participate in global clinical studies of mirvetuximab conducted by ImmunoGen. ImmunoGen will continue

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